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(chrI - chrXVI,chrMito,2-micron)

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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
NHA1 Na+/H+ exchanger (also harbouring K+/H+ activity) 
Entry:YLR138w
Alias:L3149; L9606.4
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (9.7 %) ;  |  Homologs in   Hemiascomycota (96.3 %);  Basidiomycota (32.6 %);  Fungi (96.3 %);  Eukaryota (96.3 %);  Plants (11.2 %);  Mammalia (10.3 %);  Human (9.7 %);  Bacteria (14 %);  All except yeast (96.3 %)
  • strong similarity to NA+/H+ antiporters of S.pombe and Z.rouxii
Functional Classification:
  • INTERACTION WITH THE ENVIRONMENT
    ..homeostasis
    ....homeostasis of cations
    ......homeostasis of protons | 48 Entries | Evi
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport facilities
    ....carrier (electrochemical potential-driven transport)
    ......antiporter | 14 Entries | Evi | PUBMED
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....ion transport
    ......cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.) | 122 Entries | Evi | PUBMED
TC Class:
  • The Uni/Sym/Antiporters
    ..The Uni/Sym/Antiporters
    ....The Monovalent Cation:Proton Antiporter-1 (CPA1) Family
    ......The Monovalent Cation:Proton Antiporter-1 (CPA1-4) Subfamily Type 4 | 1 Entry | Evi | PUBMED
InterPro:
Localization:  NHA1 localization details
  • cell periphery
  • plasma membrane
Phenotypes:  Disruption: NHA1 details
  • viable
___
  • nha1 null mutation shows sensitivity to sodium and lithium ions
___
  • Stress response defects
    ..Divalent cations and heavy metals
    ....Divalent cations and heavy metals sensitivity | 68 Entries
Overexpression:
  • Nha1p overproduction causes high tolerance to sodium and lithium ions
Click for larger Map
Physical Features
Coordinates:418438 - 421395 (W)
Length:2958 nt
Contig:chrXII
Exon Coordinates:418438 - 421395
GC Content:40.9 %
Protein Length:985 aa
Isoelectric Point:5.36
Molecular Weight:109370 Da
Transmembrane Domains:Begin - End / Length (aa)
12 - 33 / 22
38 - 60 / 23
103 - 125 / 23
204 - 226 / 23
246 - 265 / 20
293 - 315 / 23
327 - 349 / 23
364 - 381 / 18
412 - 434 / 23
9 TM- Domains
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z73310
EMBL: U53881
PIR: S59330
UniProtKB: Q99271
NCBI: NP_013239
Additional Links:
CYGD Tables:
  • Classification of the Major Facilitator Superfamily
    • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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