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(chrI - chrXVI,chrMito,2-micron)
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  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
SIR1 Silencing regulatory protein 
Entry:YKR101w
Classification:known protein | 5422 Entries
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (15.5 %) ;  |  Homologs in   Hemiascomycota (74.3 %);  Basidiomycota (10.6 %);  Fungi (74.3 %);  Eukaryota (74.3 %);  Plants (11.4 %);  Mammalia (13.4 %);  Human (10.1 %);  Bacteria (15.2 %);  All except yeast (74.3 %)

    Functional Classification:
    • INTERACTION WITH THE ENVIRONMENT
      ..cellular sensing and response to external stimulus
      ....chemoperception and response
      ......pheromone response, mating-type determination, sex-specific proteins | 189 Entries | Evi
    • PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
      ..nucleic acid binding
      ....DNA binding | 159 Entries | Evi | PUBMED
    • TRANSCRIPTION
      ..RNA synthesis
      ....mRNA synthesis
      ......transcriptional control | 495 Entries | Evi
    • CELL CYCLE AND DNA PROCESSING
      ..DNA processing
      ....DNA restriction or modification
      ......DNA conformation modification (e.g. chromatin) | 187 Entries | Evi | PUBMED
    Localization:  SIR1 localization details
    • nucleus
    Remarks:
    • if Sir1p is tethered to HML or HMR, independent of ORC-complex, silencing occures
    • if Sir1p is tethered to HML or HMR, there is still a dependence of S-phase for silencing
      Phenotypes:  Disruption: SIR1 details
      • viable
      Overexpression:
      • overproduction is lethal
      Click for larger Map
      Physical Features
      Coordinates:640106 - 642142 (W)
      Length:2037 nt
      Contig:chrXI
      Exon Coordinates:640106 - 642142
      GC Content:36.4 %
      Protein Length:678 aa
      Isoelectric Point:9.33
      Molecular Weight:79929.6 Da
      Retrieve Sequence: DNA /Protein
      Literature | References
      CYGD curated Lit.:PubMed
      PubMed:Search abstracts
      PubMed Central:Search full-text articles
      Sequence References:
      EMBL: M38524
      EMBL: Z28326
      PIR: S14173
      UniProtKB: P21691
      NCBI: NP_013027
      Additional Links:
      CYGD Tables:
    • Transcriptional map of chromosome XI
    • LinkOut:
    • SGD - Saccharomyces Genome Database
    • YGOB - Yeast Gene Order Browser
    • yMGV - yeast Microarray Global Viewer

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