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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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Chromosome View
  I  II  III  IV  V  VI  VII
  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
TIF1 Translation initiation factor 4A 
Entry:YKR059w
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (100 %) ;  |  Homologs in   Hemiascomycota (99.7 %);  Basidiomycota (65.5 %);  Fungi (99.7 %);  Eukaryota (99.7 %);  Plants (62 %);  Mammalia (65.3 %);  Human (63.6 %);  Bacteria (36.5 %);  All except yeast (99.7 %)

  • identical to Tif2p, strong similarity to other translation initiation factor eIF-4A proteins
Functional Classification:
InterPro:
Localization:  TIF1 localization details
  • cytoplasm
Remarks:
  • expressed to a lower extent than TIF2
  • expression of mammalian homolog fails to relieve tif1 tif2 double disruption
  • TIF1 and TIF2 are identical
  • has helicase activity
Phenotypes:  Disruption: TIF1 details
  • viable
___
  • simultaneous inactivation of TIF1 and TIF2 is lethal to the cell | PUBMED
Overexpression:
  • overexpression can suppress a mitochondrial missense mutation in COX3 | PUBMED
  • overproduction fails to complement the fal1 null or to suppress the fal1-1 mutant | PUBMED
Suppression:
  • TIF3 (STM1) is a multicopy suppressor of the tif1-1 mutant | PUBMED
  • overexpression of CES1 N-terminal part suppresses temperature sensitivity of the tif1-A79V mutant | PUBMED
Click for larger Map
Physical Features
Coordinates:554629 - 555816 (W)
Length:1188 nt
Contig:chrXI
Exon Coordinates:554629 - 555816
GC Content:40.4 %
Protein Length:395 aa
Isoelectric Point:5.02
Molecular Weight:44697.4 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: X12813
EMBL: Z28284
PIR: S05835
NCBI: NP_012397
NCBI: NP_012985
Additional Links:
CYGD Tables:
  • Transcriptional map of chromosome XI
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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