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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  I  II  III  IV  V  VI  VII
  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
URA1 Dihydroorotate dehydrogenase 
Entry:YKL216w
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (16.9 %) ;  |  Homologs in   Hemiascomycota (98.1 %);  Basidiomycota (20.1 %);  Fungi (98.1 %);  Eukaryota (98.1 %);  Plants (21.6 %);  Mammalia (22.9 %);  Human (18.6 %);  Bacteria (71.1 %);  All except yeast (98.1 %)

  • similarity to M.jannaschii and B.subtilis dihydroorotate oxidase, and mammalian dihydropyrimidine dehydrogenase
Functional Classification:
  • METABOLISM
    ..nucleotide/nucleoside/nucleobase metabolism
    ....pyrimidine nucleotide/nucleoside/nucleobase metabolism | 48 Entries | Evi | PUBMED
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....electron transport | 83 Entries | Evi | PUBMED
EC Number:
  • 1.3.99.11: Oxidoreductases
    ..Acting on the CH-CH group of donors
    ....With other acceptors
    ......dihydroorotate dehydrogenase | 1 Entry | Evi | PUBMED
Cofactor:
  • FAD flavoprotein
Pathway:
  • fourth step in pyrimidine biosynthesis
InterPro:
Localization:  URA1 localization details
  • cytoplasm
  • nucleus
Phenotypes:  Disruption: URA1 details
  • viable
Suppression:
  • mutant is functionally complemented by expression of human DHODH cDNA
Click for larger Map
Physical Features
Coordinates:25216 - 26160 (W)
Length:945 nt
Contig:chrXI
Exon Coordinates:25216 - 26160
GC Content:38.6 %
Protein Length:314 aa
Isoelectric Point:5.8
Molecular Weight:34801.1 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: M83295
EMBL: Z28216
PIR: JC1276
UniProtKB: P28272
UniProtKB: Q2XN75
NCBI: NP_012706
Additional Links:
CYGD Pathways:
  • Pyrimidine metabolic pathways
  • CYGD Tables:
  • Transcriptional map of chromosome XI
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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