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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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WUBLAST DNA/Protein

About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
DOA1 Protein involved in ubiquitin-dependent proteolysis 
Entry:YKL213c
Alias:UFD3; ZZZ4
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (14.1 %) ;  |  Homologs in   Hemiascomycota (92.1 %);  Basidiomycota (32.4 %);  Fungi (92.1 %);  Eukaryota (92.1 %);  Plants (30.3 %);  Mammalia (34.6 %);  Human (32.6 %);  Bacteria (17.1 %);  All except yeast (92.1 %)
  • similarity to rat phospholipase A2-activating protein
Functional Classification:
  • CELL CYCLE AND DNA PROCESSING
    ..DNA processing
    ....DNA recombination and DNA repair
    ......DNA repair | 159 Entries | Evi | PUBMED
  • PROTEIN FATE (folding, modification, destination)
    ..protein/peptide degradation
    ....cytoplasmic and nuclear protein degradation
    ......proteasomal degradation (ubiquitin/proteasomal pathway) | 128 Entries | Evi | PUBMED
InterPro:
Localization:  DOA1 localization details
  • cytoplasm
  • nucleus
Remarks:
    • beta-transducin (WD-40) repeats
Phenotypes:  Disruption: DOA1 details
  • viable
___
  • both zzz4-1 and null mutants are resistant to the five common volatile anaesthetics: isofluorane, halothane, enflurane, sevoflurane, and methoxyflurane
  • null mutant cells are temperature-sensitive when plated from saturated cultures, but do not have a uniform arrest phenotype
  • null mutant cells from mid-log phase cultures grow slowly at 37.5 deg
  • ufd3-1 and ufd3-2 mutants have reduced levels of free ubiquitin
___
  • Conditional phenotypes
    ..Heat-sensitivity (ts) | 313 Entries
  • Sensitivity to aminoacid analogs and other drugs
    ..other aminoacid analogs and other drugs | 51 Entries
Overexpression:
  • overproducing cells have the same sensitivity to isofluorane or temperature as wild-type cells
Suppression:
  • ufd3-1 and ufd3-2 mutants can be partially complemented by overexpression of free ubiquitin
Click for larger Map
Physical Features
Coordinates:34108 - 31961 (C)
Length:2148 nt
Contig:chrXI
Exon Coordinates:34108 - 31961
GC Content:39.7 %
Protein Length:715 aa
Isoelectric Point:4.87
Molecular Weight:79505.9 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: U39947
EMBL: Z28213
PIR: S38051
UniProtKB: P36037
NCBI: NP_012709
Additional Links:
CYGD Tables:
  • Transcriptional map of chromosome XI
    • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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