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(chrI - chrXVI,chrMito,2-micron)
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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
FAS1 Fatty-acyl-CoA synthase, beta chain 
Entry:YKL182w
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (5.9 %) ;  |  Homologs in   Hemiascomycota (98.8 %);  Basidiomycota (37.2 %);  Fungi (98.8 %);  Eukaryota (98.8 %);  Plants (5.4 %);  Mammalia (4.7 %);  Human (5 %);  Bacteria (17.4 %);  All except yeast (98.8 %)

  • strong similarity to C.albicans and Y.lipolytica fatty-acyl-CoA synthases, similarity to other fatty-acyl-CoA synthases
Functional Classification:
  • METABOLISM
    ..amino acid metabolism
    ....assimilation of ammonia, metabolism of the glutamate group
    ......metabolism of glutamine
    ........degradation of glutamine | 4 Entries | Evi | PUBMED
  • METABOLISM
    ..amino acid metabolism
    ....assimilation of ammonia, metabolism of the glutamate group
    ......metabolism of glutamate
    ........degradation of glutamate | 4 Entries | Evi | PUBMED
EC Number:
  • 1.3.1.9: Oxidoreductases
    ..Acting on the CH-CH group of donors
    ....With NAD+ or NADP+ as acceptor
    ......enoyl-[acyl-carrier-protein] reductase (NADH) | 1 Entry | Evi | PUBMED
  • 2.3.1.38: Transferases
    ..Acyltransferases
    ....Transferring groups other than amino-acyl groups
    ......[acyl-carrier-protein] S-acetyltransferase | 1 Entry | Evi | PUBMED
  • 2.3.1.39: Transferases
    ..Acyltransferases
    ....Transferring groups other than amino-acyl groups
    ......[acyl-carrier-protein] S-malonyltransferase | 2 Entries | Evi | PUBMED
  • 2.3.1.86: Transferases
    ..Acyltransferases
    ....Transferring groups other than amino-acyl groups
    ......fatty-acyl-CoA synthase | 2 Entries | Evi | PUBMED
  • 3.1.2.14: Hydrolases
    ..Acting on Ester Bonds
    ....Thioester Hydrolases
    ......oleoyl-[acyl-carrier-protein] hydrolase | 1 Entry | Evi | PUBMED
  • 4.2.1.61: Lyases
    ..Carbon-Oxygen Lyases
    ....Hydro-Lyases
    ......3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase | 1 Entry | Evi | PUBMED
InterPro:
Localization:  FAS1 localization details
  • cytoplasm
  • mitochondria
Remarks:
  • insensitive to the antibiotic thiolactomycin
  • about 5% of the product is myristoyl-CoA
  • contains acetyl transferase, enolyl reductase, dehydratase and malonyl/palmitoyl transferase
Phenotypes:  Disruption: FAS1 details
  • lethal
Click for larger Map
Physical Features
Coordinates:100676 - 106831 (W)
Length:6156 nt
Contig:chrXI
Exon Coordinates:100676 - 106831
GC Content:39.9 %
Protein Length:2051 aa
Isoelectric Point:5.64
Molecular Weight:228692 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: X74151
PIR: S34688
EMBL: Z28182
UniProtKB: P07149
NCBI: NP_012739
Additional Links:
CYGD Tables:
  • Transcriptional map of chromosome XI
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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