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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  I  II  III  IV  V  VI  VII
  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
PIR1 Protein required for tolerance to heat shock 
Entry:YKL164c
Alias:CCW6; YKL618
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (71.5 %) ;  |  Homologs in   Hemiascomycota (93.8 %);  Basidiomycota (13.5 %);  Fungi (93.8 %);  Eukaryota (93.8 %);  Plants (11.4 %);  Mammalia (14.2 %);  Human (14.2 %);  Bacteria (12.8 %);  All except yeast (93.8 %)
  • strong similarity to Pir2p and Pir3p, similarity to YJL158c, YJL159w and YJL160c
  • member of the Pir1p/Pir2p/Pir3p family of proteins
Functional Classification:
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....protein transport | 140 Entries | Evi | PUBMED
InterPro:
Localization:  PIR1 localization details
  • extracellular
  • cell wall
  • cytoplasm
  • nucleus
 TargetP: Secretory pathway  (RC = 2)
Remarks:
  • Pir isoforms are functionally redundant and confer tolerance to osmotin in naturally resistant yeast strains | PUBMED
  • PIR genes contains internal tandem repeats of 18 to 19 amino acids | PUBMED
  • cleaved at lys-arg residues perhaps by Kex2p
Phenotypes:  Disruption: PIR1 details
  • viable
___
  • pir1 pir2 double null mutant shows slow growth at 37C and high salt conditions, and are sensitive to heat shock | PUBMED
  • pir1 pir2 pir3 triple null mutant shows same phenotype as pir1 pir2 double null mutant | PUBMED
  • pir1 pir2 pir3 triple null mutants are sensitive to osmotin, a plant antifungal protein | PUBMED
  • speroblasted cells of PIR1 PIR2 PIR3 and pir1 pir2 pir3 strains are equally sensitive to osmotin | PUBMED
Overexpression:
  • overexpression of PIR proteins increases resistance to osmotin | PUBMED
Click for larger Map
Physical Features
Coordinates:142824 - 141799 (C)
Length:1026 nt
Contig:chrXI
Exon Coordinates:142824 - 141799
GC Content:45.6 %
Protein Length:341 aa
Isoelectric Point:6.1
Molecular Weight:34621.8 Da
Mature Protein:19-341
19-341
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: D13740
EMBL: Z28164
PIR: S33650
UniProtKB: Q03178
NCBI: NP_012757
Additional Links:
CYGD Tables:
  • Transcriptional map of chromosome XI
    • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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