GSFLogo GSF

 

 mipsLogo mips
GenRE

Navigation: » CYGD » Gene Report

Search ORF/Gene/Description

Chromosome
(chrI - chrXVI,chrMito,2-micron)

Catalogs:
Chromosome View
  I  II  III  IV  V  VI  VII
  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
Other

Search / View

   Advanced Search

   Index Search

MPact protein interaction

Tables, Lists and Reviews

WUBLAST DNA/Protein

About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
IXR1 Intrastrand crosslink recognition protein and transcription factor 
Entry:YKL032c
Alias:YKL245; (ORD1)
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (14.1 %) ;  |  Homologs in   Hemiascomycota (82.4 %);  Basidiomycota (16.6 %);  Fungi (82.4 %);  Eukaryota (82.4 %);  Plants (16.3 %);  Mammalia (18.1 %);  Human (18.3 %);  Bacteria (15.4 %);  All except yeast (82.4 %)
  • similarity to Abf2p and fruit fly homeotic protein Labial
Functional Classification:
  • PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
    ..nucleic acid binding
    ....DNA binding | 159 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..DNA processing
    ....DNA recombination and DNA repair
    ......DNA repair | 159 Entries | Evi | PUBMED
  • TRANSCRIPTION
    ..RNA synthesis
    ....mRNA synthesis
    ......transcriptional control | 495 Entries | Evi
InterPro:
Localization:  IXR1 localization details
  • nucleus
Remarks:
  • binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin
  • two repeated HMG-box
  • 21% glutamine
  • several polyglutamine runs typical of transcription factors
Phenotypes:  Disruption: IXR1 details
  • viable
___
  • null mutant is less sensitive to cisplatin
  • null mutant grows normally on YPD, but grows 2-3 fold slower on YPGE (glycerol, ethanol)
  • Exhibits sensitivity at 5 generations when grown in medium of pH 8. | Evi | PUBMED
___
  • Auxotrophies, carbon and nitrogen utilization defects
    ..Carbon utilization
    ....Respiratory deficiency | 173 Entries
  • Sensitivity to aminoacid analogs and other drugs
    ..other aminoacid analogs and other drugs | 51 Entries
Click for larger Map
Physical Features
Coordinates:381501 - 379708 (C)
Length:1794 nt
Contig:chrXI
Exon Coordinates:381501 - 379708
GC Content:45 %
Protein Length:597 aa
Isoelectric Point:7.84
Molecular Weight:67856.6 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z28032
PIR: S37849
UniProtKB: P33417
NCBI: NP_012893
Additional Links:
CYGD Tables:
  • Transcriptional map of chromosome XI
    • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

    © 2003 GSF - Forschungszentrum für Umwelt und Gesundheit, GmbH Ingolstädter Landstraße 1, D-85764 Neuherberg

    Imprint

    Disclaimer:
    MIPS Databases and associated information are protected by copyright. This server and its associated data and services are for academic, non-commercial use only. The GSF has no liability for the use of results, data or information which have been provided through this server. Neither the use for commercial purposes, nor the redistribution of MIPS database files to third parties nor the distribution of parts of files or derivative products to any third parties is permitted. Commercial users may contact the distributor Biomax Informatics AG.