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MPact protein interaction

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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
GRR1 Protein required for glucose repression and for glucose and cation transport 
Entry:YJR090c
Alias:CAT80; COT2; ELM4; J1885; SSU2; (SDC1)
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (10.8 %) ;  |  Homologs in   Hemiascomycota (95.1 %);  Basidiomycota (17.6 %);  Fungi (95.1 %);  Eukaryota (95.1 %);  Plants (10 %);  Mammalia (11 %);  Human (12.2 %);  Bacteria (15.2 %);  All except yeast (95.1 %)

  • weak similarity to C.elegans hypothetical protein C02F5.7
Functional Classification:
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....cellular import | 150 Entries | Evi
  • CELL TYPE DIFFERENTIATION
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......budding, cell polarity and filament formation | 313 Entries | Evi
  • METABOLISM
    ..C-compound and carbohydrate metabolism
    ....regulation of C-compound and carbohydrate metabolism | 127 Entries | Evi
  • PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
    ..nucleotide/nucleoside/nucleobase binding
    ....ATP binding | 191 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....mitotic cell cycle and cell cycle control
    ......mitotic cell cycle
    ........G1/S transition of mitotic cell cycle | 37 Entries | Evi | PUBMED
  • PROTEIN FATE (folding, modification, destination)
    ..protein modification
    ....modification by ubiquitination, deubiquitination | 79 Entries | Evi | PUBMED
  • PROTEIN FATE (folding, modification, destination)
    ..protein/peptide degradation
    ....cytoplasmic and nuclear protein degradation
    ......proteasomal degradation (ubiquitin/proteasomal pathway) | 128 Entries | Evi | PUBMED
  • PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
    ..protein binding | 392 Entries | Evi | PUBMED
EC Number:
  • 6.3.2.19: Ligases
    ..Forming Carbon-Nitrogen Bonds
    ....Acid?Amino-Acid Ligases (Peptide Synthases)
    ......ubiquitin?protein ligase | 47 Entries | Evi | PUBMED
InterPro:
Remarks:
  • constitutively expressed at low levels
  • glucose-repression and growth defects are suppressed by rgt1 mutations
  • inactive in the absence of glucose, but apparently overcomes the repressive effect of Rgt1p in low glucose
  • the Grr1p-Skp1p interaction is enhanced by glucose | PUBMED
  • the C-terminus of Grr1p probably negatively regulates the ability of Grr1p to interact with Skp1p in the absence of glucose | PUBMED
  • contains 12 tandem leucine-rich repeats
  • contains a F-box essential for association with Skp1p | PUBMED
  • both the F-box and the leucine-rich repeats are each necessary and together sufficient for Grr1p function and interaction of Grr1p with Skp1p | PUBMED
Phenotypes:  Disruption: GRR1 details
  • viable
___
  • in grr1 mutants, glucose is required for SUC2 induction, causing failure to grow on raffinose
  • mutants are wiener-shaped
  • mutants are cobalt-tolerant
  • mutants are deficient in high-affinity glucose uptake
  • mutants are defective in glucose-induction of HXT1, HXT2, HXT3, and HXT4
  • mutants are defective in glucose and cation transport and exhibit pseudohyphal differentiation
  • mutants have pleiotropic defects including glucose repression defects, morphological defects, defects of aromatic amino acid metabolism or transport, osmosensitivity, sensitivity to nitrogen starvation, and defects of cobalt and glucose transport
  • mutants are cold-sensitive for growth
  • grr1-172 has synthetic slow growth phenotype with cdc12-122, elm7-1, or elm3-1
  • grr1-161 or grr1-172 has an extragenic noncomplementation phenotype with cdc12-122
  • grr1 deletion mutant show induced SUC2 expression on 2% glucose
  • grr1 mutant show sulfite sensitivity
  • grr1-102 mutants are defective in cell separation but not cytokinesis after prolonged incubation at 13C | PUBMED
  • grr1-102 mutants show normal nuclear migration and division | PUBMED
___
  • Conditional phenotypes
    ..Cold-sensitivity (cs) | 105 Entries
  • Cell morphology and organelle mutants
    ..Budding mutants
    ....Elongated cell and bud morphologies | 32 Entries
  • Cell morphology and organelle mutants
    ..Cell wall mutants
    ....Osmotic sensitivity (Osm) | 43 Entries
  • Cell morphology and organelle mutants
    ..Cytoskeleton mutants
    ....Tubulin cytoskeleton mutants
    ......other tubulin cytoskeleton mutants | 15 Entries
  • Stress response defects
    ..Starvation sensitivity | 26 Entries
Overexpression:
  • overproduction of Grr1p in cdc34, cdc34-1 sic1 and sic1 impairs colony formation at 30C | PUBMED
  • overexpression exacerbates the growth defects of skp1-11 mutants at the permissive temperature | PUBMED
  • overexpression of C-terminal truncated Grr1p more severely exacerbates the growth defects of skp1-11 mutants at the permissive temperature | PUBMED
Suppression:
  • Fzf1p overexpression suppresses only the sulfite sensitivity
  • mutants can suppress the temperature sensitive growth phenotype of bem2 mutations but not their morphological defects | PUBMED
  • SKP1 is a multicopy suppressor of the defect induced by Grr1p overproduction in cdc34-1 sic1 cells | PUBMED
  • grr1 mutants suppress the temperature sensitive phenotype of cdc34-1 sic1 double mutants | PUBMED
  • the suppression of cdc34-1 sic1 mutants by grr1 is not due to defects in glucose repression or stabilization of G1 cyclins | PUBMED
Click for larger Map
Physical Features
Coordinates:594320 - 590865 (C)
Length:3456 nt
Contig:chrX
Exon Coordinates:594320 - 590865
GC Content:36.3 %
Protein Length:1151 aa
Isoelectric Point:6.08
Molecular Weight:132735 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z49590
EMBL: M59247
PIR: A41529
UniProtKB: P24814
NCBI: NP_012623
Additional Links:
CYGD Pathways:
  • Summary of mechanisms responsible for glucose-repression and glucose-induction
  • Proteolytic paths involved in cell cycle control
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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