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(chrI - chrXVI,chrMito,2-micron)

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  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
SUI2 Translation initiation factor eIF2, alpha chain 
Entry:YJR007w
Alias:J1429
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (14.5 %) ;  |  Homologs in   Hemiascomycota (100 %);  Basidiomycota (60.5 %);  Fungi (100 %);  Eukaryota (100 %);  Plants (48.2 %);  Mammalia (52.4 %);  Human (52 %);  Bacteria (12.8 %);  All except yeast (100 %)
  • strong similarity to mammalian translation initiation factor eIF-2 alpha chain
Functional Classification:
InterPro:
Localization:  SUI2 localization details
  • cytoplasm
Remarks:
    • phosphorylation of ser-51 by Gcn2p increases in amino acid starvation
    • ser-292 ser-294 and ser-301 are constitutively phosphorylated by casein kinase II
    • change of ser-51 to ala blocks increase of Gcn4p and change to asp permanently induces Gcn4p
Phenotypes:  Disruption: SUI2 details
  • lethal
___
  • mutants can initiate at UUG codon
  • mutation of CKII sites has synthetic growth defect with GCN2, GCN3, or GCD7
Suppression:
  • mutations can suppress the toxic effect of constitutively-activated Gcn2p, and these mutations do not affect growth rate
  • expression of mammalian homolog can rescue disruption mutant
Click for larger Map
Physical Features
Coordinates:451013 - 451927 (W)
Length:915 nt
Contig:chrX
Exon Coordinates:451013 - 451927
GC Content:36.9 %
Protein Length:304 aa
Isoelectric Point:4.94
Molecular Weight:34717.8 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: X87611
EMBL: Z49507
EMBL: X87611
PIR: A32108
EMBL: M25552
UniProtKB: P20459
NCBI: NP_012540
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
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