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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
MET18 Protein involved in NER repair and RNA polymerase II transcription 
Entry:YIL128w
Alias:MMS19
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (14.8 %) ;  |  Homologs in   Hemiascomycota (88.8 %);  Basidiomycota (24.4 %);  Fungi (88.8 %);  Eukaryota (88.8 %);  Plants (22.9 %);  Mammalia (25.5 %);  Human (24.6 %);  Bacteria (18.5 %);  All except yeast (88.8 %)
  • weak similarity to S.pombe suppressor protein sds22(+)
Functional Classification:
  • METABOLISM
    ..amino acid metabolism
    ....metabolism of the aspartate family
    ......metabolism of methionine | 35 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..DNA processing
    ....DNA recombination and DNA repair
    ......DNA repair | 159 Entries | Evi | PUBMED
  • TRANSCRIPTION
    ..RNA synthesis
    ....mRNA synthesis
    ......transcriptional control | 495 Entries | Evi
InterPro:
Localization:  MET18 localization details
  • cytoplasm
  • nucleus
Remarks:
  • Mms19p is not associated with TFIIH
  • Leu-rich
Phenotypes:  Disruption: MET18 details
  • viable
___
  • null mutant shows methionine auxotrophy and MMS sensitivity | PUBMED
  • null mutant grows slowly at 30 deg and is temperature-sensitive for growth at 37 deg
  • null mutant diploids have a severe sporulation defect
  • mms19 mutants are only moderately sensitive to irradiation with ultraviolet | PUBMED
___
  • Conditional phenotypes
    ..Heat-sensitivity (ts) | 313 Entries
  • Mating and sporulation defects
    ..Sporulation efficiency | 112 Entries
  • Auxotrophies, carbon and nitrogen utilization defects
    ..Methionine auxotrophy (Met) | 9 Entries
  • Nucleic acid metabolism defects
    ..DNA repair mutants
    ....UV light sensitivity | 41 Entries
  • Nucleic acid metabolism defects
    ..DNA repair mutants
    ....Alkylating agents sensitivity | 33 Entries
Click for larger Map
Physical Features
Coordinates:113806 - 116904 (W)
Length:3099 nt
Contig:chrIX
Exon Coordinates:113806 - 116904
GC Content:35.1 %
Protein Length:1032 aa
Isoelectric Point:5.64
Molecular Weight:117884 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z46833
EMBL: U70559
EMBL: Z47047
PIR: S53571
UniProtKB: P40469
NCBI: NP_012138
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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