| Entry: | YIL075c |
| Alias: | GVM2; SEN3 |
| Classification: | known protein | 5422 Entries | Evi
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PUBMED
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| Feature Type: | CDS |
| Features |
 |
Blast-Simap
DNA VIEW
PROTEIN VIEW
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| Similarity: |
similarity to C.elegans hypothetical protein |
| Functional Classification: | - TRANSCRIPTION
..RNA processing
....tRNA processing
| 47 Entries | Evi
- PROTEIN FATE (folding, modification, destination)
..protein modification
....protein processing (proteolytic)
| 89 Entries | Evi
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PUBMED
- PROTEIN FATE (folding, modification, destination)
..protein/peptide degradation
....cytoplasmic and nuclear protein degradation
......proteasomal degradation (ubiquitin/proteasomal pathway)
| 128 Entries | Evi
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PUBMED
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InterPro:
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| Localization: | RPN2 localization detailscytoplasmERER
..ER membranenucleusnucleus
..nuclear envelope |
| Remarks: | was also isolated as a factor exercising post-transcriptional control of SEN1, which is required for the tRNA-splicing endonuclease SEN2has an effect on the tRNA splicing systemfunctional homolog of the p112 subunit(S1) of the mammalian 19S subcomplex of the 26S proteasome complex |
| Phenotypes: | Disruption: RPN2 details___
disruption mutants are temperature sensitive, but complete deletion is lethal, see |
PUBMED
sen3-1 has defect in degradation of ubiquitin-conjugated proteins and accumulates ubiquitin-protein conjugatessen3-1 is a ts mutation with increased abundance of Sen3p fusion proteins at non-permissive temperaturemutants are defective in proteolysis by the ubiquitin pathway and the N-end rule systemmutants are defective in stress response upon cadmium exposuremutants are defective in nuclear protein transportmutants show an abnormal accumulation of tRNA intermediatesson1 sen3 and son1 cdc28-1N double mutants are inviable or very sick |
PUBMED
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Conditional phenotypes
..Heat-sensitivity (ts) | 313 Entries Stress response defects
..Divalent cations and heavy metals
....Divalent cations and heavy metals resistance | 13 Entries |
| Overexpression: | overexpression suppresses nin1-1 mutants |
| Suppression: | SON1 and SEN3 suppresors suggest that a positive component of the default mating pathway is subject to ubiquitin-mediated degradation |
PUBMED
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