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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
CTR2 Protein involved in copper transport 
Entry:YHR175w
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (9.6 %) ;  |  Homologs in   Hemiascomycota (82 %);  Basidiomycota (33.9 %);  Fungi (82 %);  Eukaryota (82 %);  Plants (22.8 %);  Mammalia (32.8 %);  Human (30 %);  Bacteria (17.8 %);  All except yeast (82 %)

  • weak similarity to C.elegans hypothetical protein
  • homolog of A.thaliana COPT1
Functional Classification:
  • INTERACTION WITH THE ENVIRONMENT
    ..homeostasis
    ....homeostasis of cations
    ......homeostasis of metal ions (Na, K, Ca etc.) | 98 Entries | Evi
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....cellular import | 150 Entries | Evi | PUBMED
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....ion transport
    ......cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.)
    ........heavy metal ion transport (Cu+, Fe3+, etc.) | 53 Entries | Evi | PUBMED
TC Class:
  • The unclassifiable, putative or spurios Transporters
    ..The Transporters of Unknown Classification
    ....The Copper Transporter-2 (Ctr2) Family
    ......The Copper Transporter-2 (CTR2-1) Subfamily Type 1 | 1 Entry | Evi | PUBMED
InterPro:
Localization:  CTR2 localization details
  • ER
Remarks:
  • Ctr2p might mediate low affinity copper uptake
    Phenotypes:  Disruption: CTR2 details
    • viable
    ___
    • ctr2 disruptant displays increased resistance to copper toxicity
    • ctr2 disruptant does not show a growth defect on a nonfermentable carbon source nor on an iron- or copper-starved medium
    • ctr2 ctr1-3 double mutant is stronger growth inhibited in presence of a copper chelator than the ctr1-2 single mutant
    ___
    • Stress response defects
      ..Divalent cations and heavy metals
      ....Divalent cations and heavy metals resistance | 13 Entries
    Overexpression:
    • overproduction confers copper sensitivity
    Click for larger Map
    Physical Features
    Coordinates:452872 - 453441 (W)
    Length:570 nt
    Contig:chrVIII
    Exon Coordinates:452872 - 453441
    GC Content:40.9 %
    Protein Length:189 aa
    Isoelectric Point:7.02
    Molecular Weight:21651.2 Da
    Transmembrane Domains:Begin - End / Length (aa)
    76 - 98 / 23
    146 - 168 / 23

    2 TM- Domains
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: U00027
    PIR: S48914
    UniProtKB: P38865
    NCBI: NP_012045
    Additional Links:
    LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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