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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
FUR1 Uracil phosphoribosyltransferase 
Entry:YHR128w
Classification:known protein | 5422 Entries
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (14 %) ;  |  Homologs in   Hemiascomycota (98.1 %);  Basidiomycota (61.9 %);  Fungi (98.1 %);  Eukaryota (98.1 %);  Plants (45.8 %);  Mammalia (34.2 %);  Human (31 %);  Bacteria (47.8 %);  All except yeast (98.1 %)

  • strong similarity to Toxoplasma gondii uracil phosphoribosyl transferase
  • similarity to Urk1p and other uracil phosphoribosyltransferases
Functional Classification:
  • METABOLISM
    ..nucleotide/nucleoside/nucleobase metabolism
    ....pyrimidine nucleotide/nucleoside/nucleobase metabolism
    ......pyrimidine nucleotide/nucleoside/nucleobase anabolism | 14 Entries | Evi | PUBMED
  • PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
    ..nucleotide/nucleoside/nucleobase binding | 225 Entries | Evi | PUBMED
EC Number:
  • 2.4.2.9: Transferases
    ..Glycosyltransferases
    ....Pentosyltransferases
    ......uracil phosphoribosyltransferase | 1 Entry | Evi | PUBMED
Pathway:
  • pyrimidine salvage pathway
InterPro:
Localization:  FUR1 localization details
  • cytoplasm
Remarks:
  • Due to comparison of closely related Saccharomyces species, the start site for FUR1/YHR128w moved from 362012 to 362117, 106 nt (35 codons) downstream. | Evi | PUBMED
    Phenotypes:  Disruption: FUR1 details
    • viable
    ___
    • mutant is resistant to 5-fluorouracil
    Click for larger Map
    Physical Features
    Coordinates:362118 - 362768 (W)
    Length:651 nt
    Contig:chrVIII
    Exon Coordinates:362118 - 362768 | Evi | PUBMED
    GC Content:40.9 %
    Protein Length:216 aa
    Isoelectric Point:5.59
    Molecular Weight:24594.7 Da
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: U10398
    PIR: JH0147
    UniProtKB: P18562
    NCBI: NP_011996
    Additional Links:
    LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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