| Entry: | YHR119w |
| Alias: | H8263.2; YTX1 |
| Classification: | known protein | 5422 Entries | Evi
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PUBMED
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| Feature Type: | CDS |
| Features |
 |
Blast-Simap
DNA VIEW
PROTEIN VIEW
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| Similarity: |
similarity to C.elegans hypothetical protein, mouse All-1 protein, human zinc finger protein HRX, D.melanogaster trxI and trxIIsimilarity to Drosophila trx and its human homolog ALL-1/HRX/MLL |
PUBMED
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| Functional Classification: | - CELL TYPE DIFFERENTIATION
..fungal/microorganismic cell type differentiation
....fungal and other eukaryotic cell type differentiation
......development of asco- basidio- or zygospore
| 167 Entries | Evi
- BIOGENESIS OF CELLULAR COMPONENTS
..nucleus
....organization of chromosome structure
| 90 Entries | Evi
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PUBMED
- CELL CYCLE AND DNA PROCESSING
..DNA processing
....DNA restriction or modification
......DNA conformation modification (e.g. chromatin)
| 187 Entries | Evi
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PUBMED
- CELL CYCLE AND DNA PROCESSING
..cell cycle
....mitotic cell cycle and cell cycle control
| 447 Entries | Evi
- PROTEIN FATE (folding, modification, destination)
..protein modification
....posttranslational modification of amino acids (e.g. hydroxylation, methylation)
| 26 Entries | Evi
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PUBMED
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| EC Number: | - 2.1.1.43: Transferases
..Transferring One-Carbon Groups
....Methyltransferases
......histone-lysine N-methyltransferase
| 9 Entries | Evi
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PUBMED
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InterPro:
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| Localization: | SET1 localization details TargetP: Mitochondrion
(RC = 4)
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| Remarks: | SET domain proteins are multifunctional chromatin regulators with activities in both eu- and heterochromatin - a role consistent with their modular structure, which combines the SET domain with additional sequence motifs of either a cysteine-rich region/zinc-finger type or the chromo domain |
PUBMED
SET or TROMO domain at the C-terminus (trithorax gene family human/Drosophila)the SET domain is sufficient for telomeric silencing |
PUBMED
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| Phenotypes: | Disruption: SET1 details___
null mutant exhibits derepression of silenced genes at telomeres and the HML silent mating-type locusmutant strains are defective in transcriptional silencing of the silent mating-type loci and telomeres |
PUBMED
the telomeric silencing defect is rescued not only by full-length episomal SET1 but also by the conserved SET domain of SET1 |
PUBMED
set1 mutant strains display other phenotypes including morphological abnormalities, stationary phase defects, and growth and sporulation defects |
PUBMED
set1 mutants outer mannoprotein layer of the cell wall is thinner than in wildtype cells |
PUBMED
set1 mutants show grater proportion of cells with G2 DNA content and increases number of large and multibudded cells |
PUBMED
set1/set1 diploid mutants do not sporulate and heterozygous diploids show reduced sporulation efficiency |
PUBMED
set1 mutants show silencing and telomeric defects |
PUBMED
set1 mutants show reduced transcription of RAM2 and HAS1 |
PUBMED
set1 mutants show reduced Ram2p activity |
PUBMED
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Mating and sporulation defects
..Sporulation efficiency | 112 Entries Cell morphology and organelle mutants
..Budding mutants
....Multibudded cells | 16 Entries Cell morphology and organelle mutants
..Cell wall mutants
....other cell wall mutants | 73 Entries Nucleic acid metabolism defects
..Transcriptional mutants
....Silencing mutants | 26 Entries |
