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MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
HXT1 Low-affinity hexose facilitator 
Entry:YHR094c
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (86.1 %) ;  |  Homologs in   Hemiascomycota (97.5 %);  Basidiomycota (35.8 %);  Fungi (97.5 %);  Eukaryota (97.5 %);  Plants (27.6 %);  Mammalia (24.7 %);  Human (24.2 %);  Bacteria (31.2 %);  All except yeast (97.5 %)

  • strong similarity to Hxt3p, Hxt5p, Hxt6p, Hxt7p, Hxt4p, Gal2p, Hxt9p and other hexose transport proteins
Functional Classification:
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....cellular import | 150 Entries | Evi
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....C-compound and carbohydrate transport
    ......sugar transport | 29 Entries | Evi | PUBMED
TC Class:
  • The Uni/Sym/Antiporters
    ..The Uni/Sym/Antiporters
    ....The Major Facilitator (MFS) Superfamily
    ......The Sugar Porter (SP) Subfamily | 32 Entries | Evi | PUBMED
InterPro:
Localization:  HXT1 localization details
  • plasma membrane
Remarks:
  • induced by glucose only at high concentration | PUBMED
  • induction depends on Grr1p | PUBMED
  • induction in high glucose is Rgt1-independent
  • Skp1p and Cdc53p are required for glucose induction of gene expression | PUBMED
  • strain expressing Hxt1p but lacking Hxt2-7p requires greater than 1% glucose for growth
  • lack of expression in the absence of glucose requires repression by Rgt1p and Ssn6p
  • expression is maximal during lag and early exponential phases of growth, decreasing upon further entry into exponential growth
    Phenotypes:  Disruption: HXT1 details
    • viable
    Suppression:
    • trk1 trk2 double null mutant can be suppressed on K+-limiting medium by gain-of function mutations of HXT1, HXT3 or GAL2 | PUBMED
    • the suppression of trk1 trk2 double null mutant by HXT1, HXT3 or GAL2 gain-of-function mutants is dependent on glucose | PUBMED
    • expression of wildtype HXT1 is sufficient to restore growth of a hxt1 hxt2 hxt3 hxt4 hxt6 hxt7 gal2 hepta null mutant on glucose containing medium | PUBMED
    Click for larger Map
    Physical Features
    Coordinates:292628 - 290916 (C)
    Length:1713 nt
    Contig:chrVIII
    Exon Coordinates:292628 - 290916
    GC Content:41.2 %
    Protein Length:570 aa
    Isoelectric Point:7.39
    Molecular Weight:63261.7 Da
    Transmembrane Domains:Begin - End / Length (aa)
    60 - 81 / 22
    117 - 134 / 18
    144 - 163 / 20
    170 - 192 / 23
    202 - 224 / 23
    237 - 256 / 20
    349 - 371 / 23
    392 - 414 / 23
    429 - 451 / 23
    464 - 486 / 23
    490 - 512 / 23

    11 TM- Domains
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: U00060
    EMBL: M38709
    EMBL: M82963
    EMBL: L07079
    PIR: S38798
    UniProtKB: P32465
    NCBI: NP_011962
    Additional Links:
    CYGD Pathways:
  • Summary of mechanisms responsible for glucose-repression and glucose-induction
  • Model for GLO1 gene induction under highly osmotic conditions
  • CYGD Tables:
  • Classification of the Major Facilitator Superfamily
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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