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(chrI - chrXVI,chrMito,2-micron)

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  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
PUT2 1-pyrroline-5-carboxylate dehydrogenase 
Entry:YHR037w
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (25.4 %) ;  |  Homologs in   Hemiascomycota (97.7 %);  Basidiomycota (49.6 %);  Fungi (97.7 %);  Eukaryota (97.7 %);  Plants (26.6 %);  Mammalia (42.1 %);  Human (42.1 %);  Bacteria (48.3 %);  All except yeast (97.7 %)
  • similarity to E.coli putA protein, Ald4p, Ald5p and other aldehyde dehydrogenases
Functional Classification:
  • METABOLISM
    ..amino acid metabolism
    ....assimilation of ammonia, metabolism of the glutamate group
    ......metabolism of glutamate
    ........biosynthesis of glutamate | 15 Entries | Evi | PUBMED
  • METABOLISM
    ..amino acid metabolism
    ....assimilation of ammonia, metabolism of the glutamate group
    ......metabolism of proline
    ........degradation of proline | 4 Entries | Evi | PUBMED
EC Number:
  • 1.5.1.12: Oxidoreductases
    ..Acting on the CH-NH group of donors
    ....With NAD+ or NADP+ as acceptor
    ......1-pyrroline-5-carboxylate dehydrogenase | 1 Entry | Evi | PUBMED
Pathway:
  • second step in the conversion of proline to glutamate
InterPro:
Localization:  PUT2 localization details
  • mitochondria
 TargetP: Mitochondrion  (RC = 4)
 Mitop2:  Mitochondrial probability - 98  %
Remarks:
  • member of the yeast ALDH family | PUBMED
  • delta-1-pyrroline-5-carboxylate dehydrogenase
  • induction by proline and is regulated by a common control element encoded by the PUT3 gene
    Phenotypes:  Disruption: PUT2 details
    • viable
    Click for larger Map
    Physical Features
    Coordinates:181970 - 183697 (W)
    Length:1728 nt
    Contig:chrVIII
    Exon Coordinates:181970 - 183697
    GC Content:40.2 %
    Protein Length:575 aa
    Isoelectric Point:6.54
    Molecular Weight:64435.4 Da
    Mature Protein:29-575
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: M10029
    EMBL: U00062
    PIR: S46738
    UniProtKB: P07275
    NCBI: NP_011902
    Additional Links:
    LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
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