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MPact protein interaction

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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
PMR1 Ca++-transporting P-type ATPase located in Golgi 
Entry:YGL167c
Alias:BSD1; DER5; G1666; (SSC1)
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (27.1 %) ;  |  Homologs in   Hemiascomycota (98.6 %);  Basidiomycota (48.9 %);  Fungi (98.6 %);  Eukaryota (98.6 %);  Plants (32.8 %);  Mammalia (48.7 %);  Human (48.2 %);  Bacteria (39.3 %);  All except yeast (98.6 %)

  • similarity to mammalian Ca2+-transporting ATPase
  • member of sarco/endoplasmic reticulum family of Ca2+ ATPases (SERCA)
  • similarity to Synechocystis cation-transporting ATPase pacL
Functional Classification:
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....cellular export and secretion | 76 Entries | Evi | PUBMED
  • INTERACTION WITH THE ENVIRONMENT
    ..homeostasis
    ....homeostasis of cations | 162 Entries | Evi
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....vesicular transport (Golgi network, etc.) | 200 Entries | Evi
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport facilities
    ....transport ATPases | 54 Entries | Evi | PUBMED
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....ion transport
    ......cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.)
    ........heavy metal ion transport (Cu+, Fe3+, etc.) | 53 Entries | Evi | PUBMED
EC Number:
  • 3.6.3.35: Hydrolases
    ..Acting on Acid Anhydrides
    ....Acting on acid anhydrides; catalysing transmembrane movement of substances
    ......manganese-transporting ATPase | 1 Entry | Evi | PUBMED
  • 3.6.3.8: Hydrolases
    ..Acting on Acid Anhydrides
    ....Acting on acid anhydrides; catalysing transmembrane movement of substances
    ......Ca2+-transporting ATPase | 6 Entries | Evi | PUBMED
TC Class:
  • The Driven Transporters
    ..The P-P Bond Hydrolysis - Driven Transporters
    ....The P-type ATPase (P-ATPase) Superfamily
    ......The Ca2+-ATPase (CaA) Subfamily | 2 Entries | Evi | PUBMED
InterPro:
Localization:  PMR1 localization details
  • ER
  • golgi
  • golgi
    ..golgi membrane
Remarks:
  • Crz1p mediates the calcineurin-dependent induction of PMR1, PMR2 and PMC1 transcription in response to Ca2+ | PUBMED
  • contains a 26 amino acid motif like calcium-binding domain of other proteins
Phenotypes:  Disruption: PMR1 details
  • viable
___
  • null mutant has secretory defects that can be reversed by addition of Ca2+ to the medium
  • mutant increases paraquat resistance in sod1 sod2 double null strain
  • mutant has elevated levels of cytosolic calcium
  • deletion causes massive accumulation of Ca2+ in the vacuoles and affects the rates of Ca2+ influx and efflux
  • bsd2-1 mutants are inositol auxotroph
  • bsd2-1 mutants are unable to derepress transcription of INO1
  • newly synthesized phosphatidylinositol is subject to accelerated turnover in bsd2-1 mutants
  • bsd2-1 mutants are defective in the expression of phospholipid biosynthetic genes
  • mutants are sensitive to EGTA | PUBMED
  • pmr1 cos16 double mutants cangrow on medium containing 0.5mM EGTA | PUBMED
  • mutant is sensitive to Mn++ , see | PUBMED
  • mutation causes reversal of sod1 defects for aerobic growth, probably by elevation of Mn++ which is known to substitute for Sod1p
___
  • Auxotrophies, carbon and nitrogen utilization defects
    ..Inositol auxotrophy (Ino) | 10 Entries
  • Cell morphology and organelle mutants
    ..Secretory mutants | 61 Entries
  • Stress response defects
    ..Divalent cations and heavy metals
    ....Divalent cations and heavy metals sensitivity | 68 Entries
Overexpression:
  • overproduction restores the pmc1 mutant tolerance to high Ca2+
Suppression:
  • overexpression of CCC1 reduces manganese toxicity in pmr1 mutant and PMR1 wild-type cells
  • overproduction of SAC1 antagonizes suppression of sec14-1 by bsd2-1
  • mutant can bypass sec14 null mutant
Click for larger Map
Physical Features
Coordinates:190474 - 187622 (C)
Length:2853 nt
Contig:chrVII
Exon Coordinates:190474 - 187622
GC Content:38.1 %
Protein Length:950 aa
Isoelectric Point:5.47
Molecular Weight:104571 Da
Transmembrane Domains:Begin - End / Length (aa)
106 - 128 / 23
290 - 312 / 23
322 - 344 / 23
811 - 830 / 20
845 - 862 / 18
883 - 905 / 23
910 - 928 / 19

7 TM- Domains
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z72690
EMBL: X85757
EMBL: M25488
PIR: A30990
UniProtKB: P13586
NCBI: NP_011348
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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