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MPact protein interaction

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About CYGD

MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
HOP2 Protein required for pairing of homologous chromosomes (see splice variants) 
Feature Type:CDS
Overlapping Feature:
  • YGL033w2 HOP2 Protein required for pairing of homologous chromosomes (Splice variant II) [435630-436356(W) CDS]
  • YGL033w1 HOP2 Protein required for pairing of homologous chromosomes (Splice variant I) [435256-436356(W) CDS]
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Paralogs ( %) ;  |  Homologs in   Hemiascomycota ( %);  Basidiomycota ( %);  Fungi ( %);  Eukaryota ( %);  Plants ( %);  Mammalia ( %);  Human ( %);  Bacteria ( %);  All except yeast ( %)

  • weak similarity to human hypothetical protein
Functional Classification:
Localization:  HOP2 localization details
  • nucleus
  • nucleus
    ..chromosome structure
Phenotypes:  Disruption: HOP2 details
  • lethal
  • viable
  • hop2 mutant shows decreased pairing of homologous chromosomes (SGD)
  • hop2-1 mutants are defcetive in meiotic gene conversion | PUBMED
  • diploid homozygous hop2-1 mutants fail to sporulate | PUBMED
  • null mutant arrests in meiotic prophase | PUBMED
  • hop2 mutant displays a uniform arrest in all yeast strains tested | PUBMED
  • hop2 mutant assembles nearly wild-type amounts of synaptonemal complexes | PUBMED
  • hop2 mutant shows delayed synapsis | PUBMED
  • hop2 mutants frequently contain polycomplexes in the nuclei which are assemblies of synaptonemal complex proteins unassociated with chromatin | PUBMED
  • hop2 mutants show chromosomes synapsed with nonhomologous partners | PUBMED
  • hop2 mutant fails to repair double strand breaks | PUBMED
  • hop2 mutant arrested in meiosis show incomplete recombination | PUBMED
  • hop2 mutant shows no axial associations | PUBMED
  • hop2 mutant shows no dissociation of Dmc1p from chromosomes | PUBMED
  • Nucleic acid metabolism defects
    ..DNA repair mutants
    ....other DNA repair mutants | 32 Entries
  • the hop2 sporulation defect is bypassed by a spo11 mutation | PUBMED
Click for larger Map
Physical Features
Coordinates:435256 - 436356 (W)
Length:1101 nt
Exon Coordinates:
GC Content: %
Protein Length: aa
Isoelectric Point:
Molecular Weight: Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z72555
EMBL: X55442
EMBL: AF078740
PIR: S64035
Additional Links:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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