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(chrI - chrXVI,chrMito,2-micron)

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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
FTR1 High affinity iron transporter 
Entry:YER145c
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (24.5 %) ;  |  Homologs in   Hemiascomycota (97.5 %);  Basidiomycota (36.2 %);  Fungi (97.5 %);  Eukaryota (97.5 %);  Plants (8.8 %);  Mammalia (13.4 %);  Human (13.4 %);  Bacteria (22.1 %);  All except yeast (97.5 %)

  • strong similarity to hypothetical S.pombe protein SPAC1F7.07c
  • similarity to Fth1p YBR207w
Functional Classification:
  • INTERACTION WITH THE ENVIRONMENT
    ..homeostasis
    ....homeostasis of cations
    ......homeostasis of metal ions (Na, K, Ca etc.) | 98 Entries | Evi
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....ion transport
    ......cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.)
    ........heavy metal ion transport (Cu+, Fe3+, etc.)
    ..........siderophore-iron transport | 12 Entries | Evi | PUBMED
TC Class:
  • The unclassifiable, putative or spurios Transporters
    ..The Transporters of Unknown Classification
    ....The Oxidase-dependent Fe2+ Transporter (OFeT) Family
    ......The Oxidase-dependent Fe2+ Transporter (OFeT-1) Subfamily Type 1 | 4 Entries | Evi | PUBMED
InterPro:
Localization:  FTR1 localization details
  • cell periphery
  • plasma membrane
  • integral membrane / endomembranes (not assigned to a specific membrane)
 TargetP: Secretory pathway  (RC = 1)
Remarks:
  • domains required for Fet3p oxidase activity and for mediation of iron uptake are separable
  • FET3 expression is required for Ftr1p transport to the plasmamembrane
  • FTR1 expression is required for apo-Fet3p to be loaded with copper
    Phenotypes:  Disruption: FTR1 details
    • viable
    ___
    • insertion mutants have a growth defect in rich medium
    • has similar mutant phenotype as fet3
    • null mutant has unmeasurable levels of the Fet3p oxidase activity due to copper deficiency
    • Exhibits sensitivity at 15 generations when grown in galactose. | Evi | PUBMED
    • Exhibits sensitivity at 15 generations when grown in medium of pH 8. | Evi | PUBMED
    • Exhibits sensitivity at 15 generations when grown in minimal +his/leu/ura medium. | Evi | PUBMED
    • Exhibits sensitivity at 5 generations when grown in synthetic complete medium. | Evi | PUBMED
    Overexpression:
    • overproduction together with Fet3p but not alone increases iron uptake
    Click for larger Map
    Physical Features
    Coordinates:461735 - 460521 (C)
    Length:1215 nt
    Contig:chrV
    Exon Coordinates:461735 - 460521
    GC Content:45 %
    Protein Length:404 aa
    Isoelectric Point:8.67
    Molecular Weight:45722.8 Da
    Transmembrane Domains:Begin - End / Length (aa)
    10 - 32 / 23
    51 - 73 / 23
    88 - 110 / 23
    149 - 171 / 23
    181 - 203 / 23
    210 - 232 / 23
    292 - 314 / 23

    7 TM- Domains
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: U18917
    PIR: S50648
    UniProtKB: P40088
    NCBI: NP_011072
    Additional Links:
    LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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