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(chrI - chrXVI,chrMito,2-micron)

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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
MAG1 3-methyladenine DNA glycosylase 
Entry:YER142c
Alias:MAG; MMS5
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (12 %) ;  |  Homologs in   Hemiascomycota (82.5 %);  Basidiomycota (13.5 %);  Fungi (82.5 %);  Eukaryota (82.5 %);  Plants (23.3 %);  Mammalia (18.9 %);  Human (11.5 %);  Bacteria (28.1 %);  All except yeast (82.5 %)
  • weak similarity to hypothetical Synechocystis protein
Functional Classification:
  • CELL RESCUE, DEFENSE AND VIRULENCE
    ..disease, virulence and defense
    ....resistance proteins
    ......chemical agent resistance | 29 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..DNA processing
    ....DNA recombination and DNA repair
    ......DNA repair | 159 Entries | Evi | PUBMED
  • PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
    ..nucleic acid binding
    ....DNA binding | 159 Entries | Evi | PUBMED
EC Number:
  • 3.2.2.21: Hydrolases
    ..Glycosylases
    ....Hydrolysing N-Glycosyl Compounds
    ......DNA-3-methyladenine glycosylase II | 2 Entries | Evi | PUBMED
Pathway:
  • base excision reapir pathway
InterPro:
Localization:  MAG1 localization details
  • cytoplasm
  • nucleus
Remarks:
  • induced in response to DNA alkylation damage
  • regulation of MAG1 and DDI1 is controlled bidirectional by the same regulatory elements
    Phenotypes:  Disruption: MAG1 details
    • viable
    ___
    • mutant has hypersensitivity to methylmethanesulfonate(MMS) and N-methyl-N^nitro-N-nitrosoguanidine
    • order of sensitivity to MMS: rad6, rad18 > rad50, rad52 >> mag1 >> apn1 > rad4, rev3
    • rad6/18/50/52 mag1 double mutants are much more sensitive to MMS
    ___
    • Nucleic acid metabolism defects
      ..DNA repair mutants
      ....Alkylating agents sensitivity | 33 Entries
    Click for larger Map
    Physical Features
    Coordinates:456031 - 455141 (C)
    Length:891 nt
    Contig:chrV
    Exon Coordinates:456031 - 455141
    GC Content:36.3 %
    Protein Length:296 aa
    Isoelectric Point:8.11
    Molecular Weight:34333 Da
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: X56662
    EMBL: U18917
    PIR: S12498
    UniProtKB: P22134
    NCBI: NP_011069
    Additional Links:
    LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
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