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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
GLC7 Ser/thr phosphoprotein phosphatase 1, catalytic chain 
Entry:YER133w
Alias:CID1; DIS2; DIS2S1
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (40.8 %) ;  |  Homologs in   Hemiascomycota (97.8 %);  Basidiomycota (86.6 %);  Fungi (97.8 %);  Eukaryota (97.8 %);  Plants (77.6 %);  Mammalia (80.8 %);  Human (80.8 %);  Bacteria (20.2 %);  All except yeast (97.8 %)

  • strong similarity to mammalian phosphoprotein phosphatases
  • S.pombe homolog is DIS2S1
Functional Classification:
  • CELL TYPE DIFFERENTIATION
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......budding, cell polarity and filament formation | 313 Entries | Evi
  • METABOLISM
    ..C-compound and carbohydrate metabolism
    ....regulation of C-compound and carbohydrate metabolism | 127 Entries | Evi | PUBMED
  • INTERACTION WITH THE ENVIRONMENT
    ..cellular sensing and response to external stimulus
    ....temperature perception and response | 19 Entries | Evi | PUBMED
  • PROTEIN FATE (folding, modification, destination)
    ..protein modification
    ....modification by phosphorylation, dephosphorylation, autophosphorylation | 186 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....mitotic cell cycle and cell cycle control
    ......cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle) | 67 Entries | Evi | PUBMED
  • TRANSCRIPTION
    ..RNA synthesis
    ....mRNA synthesis
    ......general transcription activities
    ........transcription termination | 14 Entries | Evi | PUBMED
EC Number:
  • 3.1.3.16: Hydrolases
    ..Acting on Ester Bonds
    ....Phosphoric Monoester Hydrolases
    ......phosphoprotein phosphatase | 25 Entries
InterPro:
Localization:  GLC7 localization details
  • cytoplasm
  • nucleus
  • punctate composite
Remarks:
  • expression in highest in M, lowest in G1
  • ssn6 constitutive mutant is epistatic to cid1 for very high constitutive invertase expression
  • Reg1p and Reg2p seems to regulate the activity of Gcn7p toward substrates that are phosphorylated by Snf1p
    Phenotypes:  Disruption: GLC7 details
    • lethal
    ___
    • mutants may affect cell polarity
    • null mutants arrest at G2/M
    • glc7-T152K fails in glucose repression but has normal function in glycogen metabolism
    • glc7-T152K has different level of Sip1p phosphorylation by Snf1p in immune complex assays
    • glc7-1 fails to interact properly with Gac1p regulatory subunit leading to defect in glycogen accumulation
    • glc7 mutants confer a range of traits including cell cycle arrest, 2-deoxyglucose resistance, altered levels of glycogen, sensitivity to high salt, and sporulation defects
    • mutant has constitutive invertase derepression
    • mutant has constitutive expression of maltase
    • mutant grows on sucrose in the presence of 2-deoxyglucose
    • mutants fail to accumulate glycogen and sporulate poorly
    ___
    • Mating and sporulation defects
      ..Sporulation efficiency | 112 Entries
    • Auxotrophies, carbon and nitrogen utilization defects
      ..Carbon utilization
      ....2-deoxyglucose resistance | 1 Entry
    • Auxotrophies, carbon and nitrogen utilization defects
      ..Carbon utilization
      ....Accumulation of storage carbohydrates | 11 Entries
    • Cell morphology and organelle mutants
      ..Cell wall mutants
      ....Osmotic sensitivity (Osm) | 43 Entries
    • Cell morphology and organelle mutants
      ..other cell morphology mutants | 57 Entries
    Overexpression:
    • overexpression impairs growth of cells with reduced cAMP-dependent protein kinases
    Suppression:
    • deletion of REG1 suppresses the glycogen-deficient phenotype of glc7-1
    • glycogen synthesis defect in a glc7 ts mutant is suppressed by overexpression of Pde2p
    • glc7-1 suppresses the slow growth and morphological defects of reg1 cells
    • mutants suppress defects caused by mutations in GCN2
    Click for larger Map
    Physical Features
    Coordinates:432491 - 433954 (W)
    Length:1464 nt
    Contig:chrV
    Exon Coordinates:432491 - 432667 | Evi | PUBMED
    433193 - 433954 | Evi | PUBMED
    GC Content:35.8 %
    Protein Length:312 aa
    Isoelectric Point:5.31
    Molecular Weight:35907.5 Da
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: M77175
    EMBL: L11120
    EMBL: L11120
    EMBL: U18916
    EMBL: M27070
    PIR: S32595
    UniProtKB: P32598
    NCBI: NP_011059
    Additional Links:
    CYGD Pathways:
  • Summary of mechanisms responsible for glucose-repression and glucose-induction
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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