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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
PUP3 20S proteasome subunit (beta3) 
Entry:YER094c
Alias:CST27; SCS32
Classification:known protein | 5422 Entries
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (21.2 %) ;  |  Homologs in   Hemiascomycota (98 %);  Basidiomycota (62.8 %);  Fungi (98 %);  Eukaryota (98 %);  Plants (52.2 %);  Mammalia (54.6 %);  Human (53.6 %);  Bacteria (21 %);  All except yeast (98 %)
  • strong similarity to rat RC10-Ii, human HsC10-II and bovine proteasome theta chain
Functional Classification:
  • PROTEIN FATE (folding, modification, destination)
    ..protein modification
    ....protein processing (proteolytic) | 89 Entries | Evi | PUBMED
  • PROTEIN FATE (folding, modification, destination)
    ..protein/peptide degradation
    ....cytoplasmic and nuclear protein degradation
    ......proteasomal degradation (ubiquitin/proteasomal pathway) | 128 Entries | Evi | PUBMED
EC Number:
  • 3.4.25.1: Hydrolases
    ..Acting on peptide bonds (Peptidases)
    ....Threonine endopeptidases
    ......proteasome endopeptidase complex | 14 Entries
InterPro:
Localization:  PUP3 localization details
  • ER
  • ER
    ..ER membrane
  • nucleus
  • nucleus
    ..nuclear envelope
Phenotypes:  Disruption: PUP3 details
  • lethal
___
  • pup3-1 allel on a plasmid is able to support growth of a pup3 deletion strain | PUBMED
Overexpression:
  • overexpression affect chromosome stability | PUBMED
Suppression:
  • suppressor of rpo26-31 ts mutation (Rpo26p is subunit common to nuclear RNA polymerases (RNAPs) | PUBMED
  • pup3-1 partially suppress the rpo26-31 ts phenotype (rpo26-31p accumulate at the non-permissive temperature | PUBMED
  • scs32 mutation suppress only rpo26 ts mutations but not rpo21 ts mutations | PUBMED
Click for larger Map
Physical Features
Coordinates:349342 - 348725 (C)
Length:618 nt
Contig:chrV
Exon Coordinates:349342 - 348725
GC Content:46.6 %
Protein Length:205 aa
Isoelectric Point:5.05
Molecular Weight:22605 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: M88470
EMBL: U18839
PIR: S29251
UniProtKB: P25451
NCBI: NP_011020
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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