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(chrI - chrXVI,chrMito,2-micron)

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MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
ARG5,6 Acetylglutamate kinase and acetylglutamyl-phosphate reductase 
Entry:YER069w
Alias:ARGB; ARGC; ARG5; ARG6
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (11.2 %) ;  |  Homologs in   Hemiascomycota (95 %);  Basidiomycota (50.4 %);  Fungi (95 %);  Eukaryota (95 %);  Plants (13.8 %);  Mammalia (13.8 %);  Human (13.6 %);  Bacteria (21.8 %);  All except yeast (95 %)

  • strong similarity to S.pombe and N.crassa acetylglutamate kinase
  • similarity to M.jannaschii N-acetyl-gamma-glutamyl-phosphate reductase
Functional Classification:
  • METABOLISM
    ..amino acid metabolism
    ....assimilation of ammonia, metabolism of the glutamate group
    ......metabolism of arginine
    ........biosynthesis of arginine | 12 Entries | Evi | PUBMED
  • METABOLISM
    ..secondary metabolism
    ....metabolism of secondary products derived from primary amino acids
    ......metabolism of nonprotein amino acids | 10 Entries | Evi | PUBMED
EC Number:
  • 1.2.1.38: Oxidoreductases
    ..Acting on the aldehyde or oxo group of donors
    ....With NAD+ or NADP+ as acceptor
    ......N-acetyl-?-glutamyl-phosphate reductase | 1 Entry | Evi | PUBMED
  • 2.7.2.8: Transferases
    ..Transferring Phosphorus-Containing Groups
    ....Phosphotransferases with a carboxy group as acceptor
    ......acetylglutamate kinase | 1 Entry | Evi | PUBMED
Pathway:
  • arginine biosynthesis | catalyzes second and third step in arginine biosynthesis
InterPro:
Localization:  ARG5,6 localization details
  • mitochondria
 TargetP: Mitochondrion  (RC = 2)
 Mitop2:  Mitochondrial probability - 97  %
Remarks:
    • processing after mitochondrial import separates the two enzymes
Phenotypes:  Disruption: ARG5,6 details
  • viable
___
  • Exhibits sensitivity at 15 generations when grown in minimal +his/leu/ura medium. | Evi | PUBMED
Click for larger Map
Physical Features
Coordinates:295408 - 297999 (W)
Length:2592 nt
Contig:chrV
Exon Coordinates:295408 - 297999
GC Content:40.2 %
Protein Length:863 aa
Isoelectric Point:8.42
Molecular Weight:94869.7 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: X57017
EMBL: U18813
PIR: S16807
UniProtKB: Q01217
NCBI: NP_010992
Additional Links:
CYGD Tables:
  • Putative targets of the GCN4 transcription factor
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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