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(chrI - chrXVI,chrMito,2-micron)

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MPact protein interaction

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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
MEI4 Meiosis-specific protein 
Entry:YER044c-a
Classification:known protein | 5422 Entries
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (8.8 %) ;  |  Homologs in   Hemiascomycota (25 %);  Basidiomycota (8.1 %);  Fungi (25 %);  Eukaryota (25 %);  Plants (12.3 %);  Mammalia (13.5 %);  Human (8.8 %);  Bacteria (16.8 %);  All except yeast (25 %)

  • weak similarity to Sip4p
Functional Classification:
  • CELL TYPE DIFFERENTIATION
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......development of asco- basidio- or zygospore | 167 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..DNA processing
    ....DNA recombination and DNA repair
    ......DNA recombination
    ........meiotic recombination | 39 Entries | Evi | PUBMED
Remarks:
  • as in mer2, axial elements of the synaptonemal complex form but synapsis does not take place
  • expressed only in meiosis
  • deletion of HOP1 or RED1 markedly reduce DSB formation
  • Rad50p, Xrs2p, Mre11p and Sae2p are required for DSB formation
    Phenotypes:  Disruption: MEI4 details
    • viable
    ___
    • mutants undergo no recombination
    • in mei4 rec104 double mutants first division of meiosis occures earlier (1h) than in a wt strain | PUBMED
    ___
    • Nucleic acid metabolism defects
      ..Recombination mutants | 55 Entries
    Click for larger Map
    Physical Features
    Coordinates:239773 - 238459 (C)
    Length:1315 nt
    Contig:chrV
    Exon Coordinates:239773 - 239711 | Evi | PUBMED
    239622 - 238459 | Evi | PUBMED
    GC Content:34.7 %
    Protein Length:408 aa
    Isoelectric Point:9.6
    Molecular Weight:48215 Da
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: M84765
    PIR: S20119
    UniProtKB: P29467
    NCBI: NP_010963
    Additional Links:
    CYGD Pathways:
  • The multiple roles of Mre11 complex in repair and recombination
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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