| Entry: | YER026c |
| Alias: | PSS; PSS1 |
| Classification: | known protein | 5422 Entries |
| Feature Type: | CDS |
| Features |
 |
Blast-Simap
DNA VIEW
PROTEIN VIEW
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| Similarity: |
partial homology between the structures of this yeast enzyme and phosphatidylglycerophosphate synthase of E.coli has been found (see D00171) |
| Functional Classification: | - METABOLISM
..lipid, fatty acid and isoprenoid metabolism
....membrane lipid metabolism
......phospholipid metabolism
| 68 Entries | Evi
|
| EC Number: | - 2.7.8.8: Transferases
..Transferring Phosphorus-Containing Groups
....Transferases for other substituted phosphate groups
......CDP-diacylglycerol?serine O-phosphatidyltransferase
| 1 Entry | Evi
|
|
Pathway: | synthesis of phosphatidylcholine (bremer-greenberg pathway) |
|
InterPro:
| |
| Localization: | CHO1 localization detailsERER
..ER membranemitochondriamicrosomes
Mitop2:
Mitochondrial probability - 96
%
|
| Remarks: | phosphatidylserine synthasephosphorylation is negligible at stationary phaseopi1 mutants have no regulation of INO1 or CHO1 in response to inositol cAMP-specific phosphorylation occurs on a single serine residueremoval of first AUG results in an inactive form that is mainly cytoplasmic, but retains enough activity to complement null mutantmechanism of dual localization is yet unknowncontains CDP-alcohol phosphotransferase motif: Asp-Gly-(X)2-Ala-Arg-(X)8-Gly-(X)3-Asp-(X)3-Asp |
PUBMED
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| Phenotypes: | Disruption: CHO1 details___
mutants have ethanolamine-choline auxotrophy and are defective in synthesis of phosphatidylcholine ___
Auxotrophies, carbon and nitrogen utilization defects
..other auxotrophies, carbon and nitrogen utilization defects | 20 Entries Carbohydrate and lipid biosynthesis defects
..other carbohydrate and lipid biosynthesis defects | 36 Entries |
| Suppression: | overexpression of Pel1p in a cho1 null mutant can not restore wild-type properties |
