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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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WUBLAST DNA/Protein

About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
VPS52 Subunit of VP51-54 complex, required for protein sorting at the yeast late Golg 
Entry:YDR484w
Alias:D8035.27; SAC2
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Overlapping Feature:
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (14.9 %) ;  |  Homologs in   Hemiascomycota (92.8 %);  Basidiomycota (21.1 %);  Fungi (92.8 %);  Eukaryota (92.8 %);  Plants (21.9 %);  Mammalia (17.2 %);  Human (16.7 %);  Bacteria (19.3 %);  All except yeast (92.8 %)
  • weak similarity to Bud2p
Functional Classification:
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....vesicular transport (Golgi network, etc.) | 200 Entries | Evi | PUBMED
  • BIOGENESIS OF CELLULAR COMPONENTS
    ..cytoskeleton/structural proteins
    ....actin cytoskeleton | 96 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....cell cycle dependent cytoskeleton reorganization
    ......cell cycle dependent actin filament reorganization | 7 Entries | Evi | PUBMED
  • PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
    ..protein binding | 392 Entries | Evi | PUBMED
InterPro:
Localization:  VPS52 localization details
  • cytoskeleton
  • golgi
  • golgi
    ..golgi membrane
  • punctate composite
Phenotypes:  Disruption: VPS52 details
  • viable
___
  • null mutant and point mutant sac2-1 have cold-sensitive phenotypes
  • Mutation of VPS52, VPS53, or VPS54 results in the missorting of 70% of the vacuolar hydrolase carboxypeptidase Y as well as the mislocalization of late Golgi membrane proteins to the vacuole | PUBMED
  • Exhibits sensitivity at 5 generations when grown in medium of pH 8. | Evi | PUBMED
  • Exhibits sensitivity at 5 generations when grown in 1 M NaCl. | Evi | PUBMED
___
  • Conditional phenotypes
    ..Cold-sensitivity (cs) | 105 Entries
Suppression:
  • suppression of act1-1 by sac2-1 is strain-dependent
  • null mutant suppresses temperature sensitive growth defect of act1-1, but apparently in combination with another unidentified gene
Click for larger Map
Physical Features
Coordinates:1422755 - 1424680 (W)
Length:1926 nt
Contig:chrIV
Exon Coordinates:1422755 - 1424680
GC Content:33.3 %
Protein Length:641 aa
Isoelectric Point:5.53
Molecular Weight:74333.3 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: U33050
PIR: S69651
UniProtKB: P39904
NCBI: NP_010772
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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