GSFLogo GSF

 

mipsLogo mips
GenRE
Search ORF/Gene/Description

Chromosome
(chrI - chrXVI,chrMito,2-micron)

Catalogs:
Chromosome View
  I  II  III  IV  V  VI  VII
  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
Other

Search / View

   Advanced Search

   Index Search

MPact protein interaction

Tables, Lists and Reviews

WUBLAST DNA/Protein

About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
PPZ2 Protein ser/thr phosphatase of the PP-1 family 
Entry:YDR436w
Alias:D9461.22
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (61.3 %) ;  |  Homologs in   Hemiascomycota (94.5 %);  Basidiomycota (39.7 %);  Fungi (94.5 %);  Eukaryota (94.5 %);  Plants (27.1 %);  Mammalia (27.8 %);  Human (27.7 %);  Bacteria (13.1 %);  All except yeast (94.5 %)

  • belongs to the PP-Z subfamily of the PPP family of phosphatases
  • strong similarity to Ppz1p and other phosphoprotein phosphatases
Functional Classification:
  • INTERACTION WITH THE ENVIRONMENT
    ..homeostasis
    ....homeostasis of cations
    ......homeostasis of metal ions (Na, K, Ca etc.) | 98 Entries | Evi | PUBMED
  • CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM
    ..cellular signalling
    ....enzyme mediated signal transduction
    ......protein kinase | 57 Entries | Evi | PUBMED
  • PROTEIN FATE (folding, modification, destination)
    ..protein modification
    ....modification by phosphorylation, dephosphorylation, autophosphorylation | 186 Entries | Evi | PUBMED
EC Number:
  • 3.1.3.16: Hydrolases
    ..Acting on Ester Bonds
    ....Phosphoric Monoester Hydrolases
    ......phosphoprotein phosphatase | 25 Entries
InterPro:
Localization:  PPZ2 localization details
  • cytoplasm
  • ambiguous
Phenotypes:  Disruption: PPZ2 details
  • viable
___
  • mutants are osmosensitive
  • ppz1 ppz2 double mutants have temperature-sensitive osmoremedial cell lysis defect
  • mutations affect pseudohyphal growth
  • mutants are affected in pseudohyphal growth
  • null mutant has little affect on salt tolerance
  • ppz1 ppz2 double null mutant has more salt tolerance than ppz1 alone
  • ppz1 ppz2 double null mutant has same Li+ influx rate but much faster efflux rate than wild-type
  • ppz1 ppz2 double null mutant has much higher level of Ena1p which is responsible for Li+ efflux
  • ppz1 ppz2 double null mutant has increased sensitivity to caffeine leading to cell lysis
___
  • Cell morphology and organelle mutants
    ..Budding mutants
    ....Pseudohyphae formation | 31 Entries
  • Cell morphology and organelle mutants
    ..Cell wall mutants
    ....Osmotic sensitivity (Osm) | 43 Entries
Overexpression:
  • overproduction suppresses Mpk1 null mutation
  • overproduction suppresses rho1-104 temperature-sensitive mutation
Click for larger Map
Physical Features
Coordinates:1334813 - 1336945 (W)
Length:2133 nt
Contig:chrIV
Exon Coordinates:1334813 - 1336945
GC Content:44 %
Protein Length:710 aa
Isoelectric Point:9.37
Molecular Weight:78491.6 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: U33050
EMBL: U33007
PIR: S35674
NCBI: NP_010724
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

  • To submit new information about this entry, please write to

    © 2003 GSF - Forschungszentrum für Umwelt und Gesundheit, GmbH Ingolstädter Landstraße 1, D-85764 Neuherberg

    Imprint

    Disclaimer:
    MIPS Databases and associated information are protected by copyright. This server and its associated data and services are for academic, non-commercial use only. The GSF has no liability for the use of results, data or information which have been provided through this server. Neither the use for commercial purposes, nor the redistribution of MIPS database files to third parties nor the distribution of parts of files or derivative products to any third parties is permitted. Commercial users may contact the distributor Biomax Informatics AG.