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MPact protein interaction

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About CYGD

MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
RPP2B 60S large subunit acidic ribosomal protein 
Alias:D9481.1; D9509.2; L12EIA; L36; RPLA4; RPL45; YPA1; (YPA1)
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Paralogs (61.8 %) ;  |  Homologs in   Hemiascomycota (97.3 %);  Basidiomycota (70.2 %);  Fungi (97.3 %);  Eukaryota (97.3 %);  Plants (61.6 %);  Mammalia (57.4 %);  Human (56.5 %);  Bacteria (18.2 %);  All except yeast (97.3 %)

  • strong similarity to rpP2A and acidic ribosomal P2 proteins
Functional Classification:
Localization:  RPP2B localization details
  • cytoplasm
 TargetP: Secretory pathway  (RC = 3)
    • phosphorylation on S19 is required for function
    • phosphorylated by "60S" kinase
    • has a bilateral hydrophobic zipper that is proposed to play a role in association with other acidic ribosomal proteins
    • most abundant acidic ribosomal protein
Phenotypes:  Disruption: RPP2B details
  • viable
  • triple or quadruple disruptants of RPP1A RPP1B RPP2A RPP2B are viable but have a cold-sensitive phenotype
  • quadruple disruptants of RPP1A RPP1B RPP2A RPP2B have acidic phosphoprotein-deficient ribosomes
  • quadruple disruptants of RPP1A RPP1B RPP2A RPP2B are unable to sporulate
  • quadruple disruptants of RPP1A RPP1B RPP2A RPP2B have a different 2D gel pattern from wild-type cells with some proteins absent and others more highly expressed
Click for larger Map
Physical Features
Coordinates:1239484 - 1239816 (W)
Length:333 nt
Exon Coordinates:1239484 - 1239816
GC Content:47.7 %
Protein Length:110 aa
Isoelectric Point:4.11
Molecular Weight:11050.1 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: U32274
EMBL: M26505
EMBL: J03761
EMBL: U28373
PIR: A35109
UniProtKB: P02400
NCBI: NP_010670
Additional Links:
CYGD Tables:
  • S. cerevisiae Cytoplasmic Ribosomal Nomenclature
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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