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| Search ORF/Gene/Description |
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Chromosome
(chrI - chrXVI,chrMito,2-micron) |
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| Entry: | YDR113c | | Alias: | LOC6; YD9727.08 | | Classification: | known protein | 5422 Entries | | Feature Type: | CDS | | Features |  |
Blast-Simap
DNA VIEW
PROTEIN VIEW
| | Similarity: |
weak similarity to Streptococcus M protein | | Functional Classification: | - CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transport routes
....nuclear transport
| 85 Entries | Evi
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PUBMED
- CELL CYCLE AND DNA PROCESSING
..cell cycle
....mitotic cell cycle and cell cycle control
......cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle)
| 67 Entries | Evi
- PROTEIN FATE (folding, modification, destination)
..protein targeting, sorting and translocation
| 280 Entries | Evi
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PUBMED
- PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
..protein binding
| 392 Entries | Evi
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PUBMED
| | Localization: | PDS1 localization details | | Remarks: | degraded at the time of anaphase initiationnondegradable derivatives inhibit the onset of anaphasedirectly ubiquitinated by Xenopus APCnot needed during anaphasemust act before or during S-phase, probably during spindle formationcheckpoint effect is only for chromosome separation and spindle elongation, not for DNA replication, budding or cytokinesiscdc20-3 mutant fail to degrades Pds1p and Clb2p and impairs separation of sister chromatides |
PUBMED
has bipartite structure with pI of 11.1 for amino acids 1-175 and pI of 3.9 for amino acids 176-343has a putative cyclin destruction box RLPLAAkN at amino acids 85-93overproduced protein is stable in S/G2/M but unstable in G1protein content peaks at M phase and is degraded in early G1 | | Phenotypes: | Disruption: PDS1 details___
null mutant has a high rate of chromosome loss and is lethal at 36 degin null mutant at 36 deg, spindle fails to elongate and spindle pole bodies tend to stay in same cellmutant does not have cell cycle arrest at 37 degpds1-1 mutants exhibit frequent cell death and have a 300-fold increase in chromosome losspds1-1 mutants are unable to elongate their spindles during anaphase at 37 degcell cycle progression of mutant cells is uncoupled from the completion of anaphasepds1 deletion mutant does not induce early separation of sister chromatids under normal conditions |
PUBMED
rsi1-8 pds1 delta can overcome the abaphase block of rsi1 mutants, but arrest then in telophase |
PUBMED
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Conditional phenotypes
..Heat-sensitivity (ts) | 313 Entries Cell cycle defects
..other cell cycle defects | 207 Entries |
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