| Entry: | YDR002w |
| Alias: | CST20; D2960; HTN1; SFO1; YD8119.08; (RBP1) |
| Classification: | known protein | 5422 Entries |
| Feature Type: | CDS |
| Features |
 |
Blast-Simap
DNA VIEW
PROTEIN VIEW
|
| Similarity: |
strong similarity to human GTP binding protein RanBP1similarity to Yrb2p |
| Functional Classification: | - CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transport routes
....nuclear transport
| 85 Entries | Evi
|
PUBMED
- CELL CYCLE AND DNA PROCESSING
..cell cycle
....mitotic cell cycle and cell cycle control
......mitotic cell cycle
........G1/S transition of mitotic cell cycle
| 37 Entries | Evi
|
PUBMED
- PROTEIN FATE (folding, modification, destination)
..protein/peptide degradation
....cytoplasmic and nuclear protein degradation
......proteasomal degradation (ubiquitin/proteasomal pathway)
| 128 Entries | Evi
|
PUBMED
- PROTEIN FATE (folding, modification, destination)
..protein targeting, sorting and translocation
| 280 Entries | Evi
|
PUBMED
- PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
..protein binding
| 392 Entries | Evi
|
PUBMED
- CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transported compounds (substrates)
....RNA transport
| 86 Entries | Evi
|
PUBMED
|
|
InterPro:
| |
| Localization: | YRB1 localization details |
| Remarks: | may interact with GSP1/GSP2 and PRP20 in an intracellular signalling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membranemay potentiate the action of RANGAP1 (RNA1) on GSP1, thus playing the role of a negative regulator of the GSP1mammalian homolog binds to Ran and stimulates activity of RanGAP contains a Ran-binding protein (rbp1) motif |
| Phenotypes: | Disruption: YRB1 details___
ts mutants at the non-permissive temperature are defective in nuclear protein transport and RNA exportnull mutant spores fail to germinate ___
Conditional phenotypes
..Heat-sensitivity (ts) | 313 Entries Mating and sporulation defects
..Sporulation efficiency | 112 Entries |
| Overexpression: | overexpression causes sensitivity to hydroxyurea and UV radiation, DNA lesions, and lethality in rad9 mutantsoverexpression is nearly lethal in cells defective for the Mad2p checkpointoverexpression affect chromosome stability |
PUBMED
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