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| Search ORF/Gene/Description |
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Chromosome
(chrI - chrXVI,chrMito,2-micron) |
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| Entry: | YDL101c | | Alias: | D2370 | | Classification: | known protein | 5422 Entries | Evi
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PUBMED
| | Feature Type: | CDS | | Features |  |
Blast-Simap
DNA VIEW
PROTEIN VIEW
| | Similarity: |
similarity to Ca2+/calmodulin-dependent protein kinase Cmk1psimilarity to Rck1/Rck2p | | Functional Classification: | - CELL RESCUE, DEFENSE AND VIRULENCE
..stress response
....DNA damage response
| 77 Entries | Evi
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PUBMED
- CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM
..cellular signalling
| 199 Entries | Evi
- CELL CYCLE AND DNA PROCESSING
..DNA processing
....DNA recombination and DNA repair
......DNA repair
| 159 Entries | Evi
- PROTEIN FATE (folding, modification, destination)
..protein modification
....modification by phosphorylation, dephosphorylation, autophosphorylation
| 186 Entries | Evi
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PUBMED
- CELL CYCLE AND DNA PROCESSING
..cell cycle
....mitotic cell cycle and cell cycle control
......cell cycle arrest
| 21 Entries | Evi
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PUBMED
- CELL CYCLE AND DNA PROCESSING
..cell cycle
....mitotic cell cycle and cell cycle control
......cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle)
| 67 Entries | Evi
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PUBMED
| | EC Number: | - 2.7.1.37: Transferases
..Transferring Phosphorus-Containing Groups
....Phosphotransferases with an Alcohol Group as Acceptor
......now divided into EC 2.7.11.1, EC 2.7.11.8 - EC 2.7.11.13, EC 2.7.11.21, EC 2.7.11.22, EC 2.7.11.24, EC 2.7.11.25, EC 2.7.11.30 and EC 2.7.12.1
| 65 Entries | Evi
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PUBMED
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InterPro:
| | | Localization: | DUN1 localization details | | Remarks: | necessary for induction of Rnr3p and DNA repair genes after DNA damagea high basal level of DIN7 expression is found in strains in which the DUN1 gene was inactivated by transposon insertionDun1 may be a negative regulator of the DIN7 gene expressionthe human fork head transcription factor CHES1 suppress checkpoint defective strains including mec1, rad9, rad24, dun1 and rad53expression of CHES1 results in G2 delay after UV irradiation contains a forkhead-associated (FHA) domainphosphorylation increases in response to DNA damage in a Dun1p-dependent manner, suggesting autophosphorylationphosphorylation increases 6-fold after exposure to methylmethanesulfonate | | Phenotypes: | Disruption: DUN1 details___
null mutants fail to induce Rnr1p, Rnr2p, and Rnr3p but do induce some other DNA repair genes after DNA-damagemutants are sensitive to UV, hydroxyurea, and methylmethanesulfonate, but G2 checkpoint is intactnull mutants have reduced DNA damage inducibility of RNR2, RNR3 and RNR4 |
PUBMED
rnr4-99 dun1-3 mutants have increased RNR3 transcript levels |
PUBMED
in dun1 deletion mutants the transcript levels of RNR2 and RNR4 are increased after DNA damage |
PUBMED
Exhibits sensitivity at 5 generations when grown in 10 uM nystatin. | Evi
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PUBMED
___
Nucleic acid metabolism defects
..DNA repair mutants
....UV light sensitivity | 41 Entries Nucleic acid metabolism defects
..DNA repair mutants
....Alkylating agents sensitivity | 33 Entries Nucleic acid metabolism defects
..DNA repair mutants
....other DNA repair mutants | 32 Entries | | Overexpression: | the lethality of rnr4 dun1 double mutants can be suppressed by overexpression of RNR1 and RNR3 |
PUBMED
| | Suppression: | CHES1 is a human fork head transcription factor |
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