| Entry: | YCL035c |
| Classification: | known protein | 5422 Entries | Evi
|
PUBMED
|
| Feature Type: | CDS |
| Features |
 |
Blast-Simap
DNA VIEW
PROTEIN VIEW
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| Similarity: |
strong similarity to TTR1/GRX2 |
| Functional Classification: | - CELL RESCUE, DEFENSE AND VIRULENCE
..stress response
....oxidative stress response
| 55 Entries | Evi
|
PUBMED
- CELL RESCUE, DEFENSE AND VIRULENCE
..detoxification
....detoxification by modification
| 8 Entries | Evi
|
PUBMED
- CELL RESCUE, DEFENSE AND VIRULENCE
..detoxification
....oxygen and radical detoxification
......glutathione conjugation reaction
| 5 Entries | Evi
|
PUBMED
- CELL RESCUE, DEFENSE AND VIRULENCE
..detoxification
....oxygen and radical detoxification
......peroxidase reaction
| 7 Entries | Evi
|
PUBMED
- CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transported compounds (substrates)
....electron transport
| 83 Entries | Evi
|
PUBMED
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| EC Number: | - 1.11.1.9: Oxidoreductases
..Acting on a peroxide as acceptor
....Peroxidases
......glutathione peroxidase
| 5 Entries | Evi
|
PUBMED
- 2.5.1.18: Transferases
..Transferring Alkyl or Aryl Groups, Other than Methyl Groups
....Transferring Alkyl or Aryl Groups, Other than Methyl Groups
......glutathione transferase
| 5 Entries | Evi
|
PUBMED
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|
InterPro:
| |
| Localization: | GRX1 localization details |
| Remarks: | Grx1p- and Grx2p-lacZ-fusion assy show different expression under stress conditions (hydrogen peroxide, menadione, diamide, heat shock, stationary phase) |
PUBMED
Grx1p and Grx2p may act in the primary defense against oxidative damage |
PUBMED
|
| Phenotypes: | Disruption: GRX1 details___
grx1 grx2 double mutant is viable and grow on minimal medium at the same rate than the wild-type |
PUBMED
grx1 grx2 double mutant is sensitive to tert-butyl hydroperoxide during exponential and stationary growth phase |
PUBMED
grx1 mutant is sensitive to oxidative stress induced by superoxide |
PUBMED
grx1 mutant is sensitive to menadione during stationary growth phase |
PUBMED
grx1 mutant is more resistant to diamide than the wild-type cells |
PUBMED
grx1 mutant has no affect on the GSH metabolism |
PUBMED
___
Stress response defects
..Oxidizing agents
....Menadione
......Menadione sensitivity | 3 Entries Stress response defects
..Oxidizing agents
....Diamide
......Diamide resistance | 1 Entry |
| Overexpression: | GRX1 and GRX2 overexpression causes increased resistance to oxidative stress induced by hydrogen peroxide and superoxide |
PUBMED
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