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MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
CDC28 Cyclin-dependent protein kinase 
Entry:YBR160w
Alias:CDK1; ELM7; HSL5; SRM5; YBR1211
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (52.4 %) ;  |  Homologs in   Hemiascomycota (99.7 %);  Basidiomycota (68.1 %);  Fungi (99.7 %);  Eukaryota (99.7 %);  Plants (64.4 %);  Mammalia (63.1 %);  Human (62.8 %);  Bacteria (21.1 %);  All except yeast (99.7 %)

  • belongs to the CDC2/CDC28 subfamily of ser/thr protein kinases
Functional Classification:
  • CELL TYPE DIFFERENTIATION
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......budding, cell polarity and filament formation | 313 Entries | Evi
  • CELL CYCLE AND DNA PROCESSING
    ..DNA processing
    ....DNA synthesis and replication | 138 Entries | Evi
  • PROTEIN FATE (folding, modification, destination)
    ..protein modification
    ....modification by phosphorylation, dephosphorylation, autophosphorylation | 186 Entries | Evi
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....mitotic cell cycle and cell cycle control
    ......mitotic cell cycle
    ........G1/S transition of mitotic cell cycle | 37 Entries | Evi
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....mitotic cell cycle and cell cycle control
    ......mitotic cell cycle
    ........S phase of mitotic cell cycle | 7 Entries | Evi
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....mitotic cell cycle and cell cycle control
    ......mitotic cell cycle
    ........G2/M transition of mitotic cell cycle | 50 Entries | Evi
EC Number:
  • 2.7.1.37: Transferases
    ..Transferring Phosphorus-Containing Groups
    ....Phosphotransferases with an Alcohol Group as Acceptor
    ......now divided into EC 2.7.11.1, EC 2.7.11.8 - EC 2.7.11.13, EC 2.7.11.21, EC 2.7.11.22, EC 2.7.11.24, EC 2.7.11.25, EC 2.7.11.30 and EC 2.7.12.1 | 65 Entries
InterPro:
Localization:  CDC28 localization details
  • cytoplasm
  • nucleus
Remarks:
  • dephosphorylation of Tyr19 is required for spindle pole body separation
  • activation of Cdc28p protein kinase activity is required for polarization of the actin cytoskeleton
  • activation of Pkc1p is mediated via CDC28-dependent stimulation of PC-PLC activity
  • tyrosine phosphorylation is not required for pseudohyphal growth
  • purified p40SIC inhibits Cdc6/Cdc28 interaction
  • Cln2p phosphorylation is dependent on Cdc28p and promotes the rapid degradation of Cln2p
  • essential target of staurosporine | PUBMED
    Phenotypes:  Disruption: CDC28 details
    • lethal
    ___
    • mutant cdc28-1N is deficient in plasmid maintenance due to defect in initiating DNA replication
    • mutant cdc28-1N arrests with a short spindle
    • mutant cdc28-1N arrests in G2 mitosis | PUBMED
    • cdc28-E19 mutants (Tyr-19 replaced by glutamic acid) performs Start-related functions, complete DNA synthesis, exhibit high levels of CLB2-associated kinase activity but fails to form bipolar spindle
    • cdc28-1 mutants arrested at G1 show centromeres skewed to the side of the nucleus containing the spindle pole | PUBMED
    • mutated cdc28 that cannot be phosphorylated on thr169 suppresses the phenotype of mutated cdc55
    • son1 sen3 and son1 cdc28-1N double mutants are inviable or very sick | PUBMED
    • cdc28-109 mutant is temperature sensitive | PUBMED
    • cdc28-109 mutant exhibits a mixed cell division arrest at 37C with cells both in G1 and G2 | PUBMED
    • cdc28-109 mutant exhibits slow progression through S/G2/M phases at permissive temperature | PUBMED
    • cdc28-109 mutant show inhibited histone H1 kinase activity at 37C | PUBMED
    • cdc28-109 mutant contains a single mutation changing guanine-541 to adenine, leading to glutatmate-181 changing to lysine | PUBMED
    ___
    • Conditional phenotypes
      ..Heat-sensitivity (ts) | 313 Entries
    • Nucleic acid metabolism defects
      ..DNA replication mutants
      ....other DNA replication mutants | 19 Entries
    Suppression:
    • mutant is functionally complemented by expression of human CDC2, CDK2, or CDK3 cDNA
    Click for larger Map
    Physical Features
    Coordinates:560072 - 560968 (W)
    Length:897 nt
    Contig:chrII
    Exon Coordinates:560072 - 560968
    GC Content:41.1 %
    Protein Length:298 aa
    Isoelectric Point:8.5
    Molecular Weight:34061.7 Da
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: Z36029
    PIR: A00657
    UniProtKB: P00546
    NCBI: NP_009718
    Additional Links:
    CYGD Pathways:
  • Cell cycle control of DNA replication in S. cerevisiae
  • Model of the Yeast cell integrity signal transduction pathways
  • Regulatory pathwayss involving Cyclin-CDK complexes
  • Proteolytic paths involved in cell cycle control
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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