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| Search ORF/Gene/Description |
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Chromosome
(chrI - chrXVI,chrMito,2-micron) |
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| Entry: | YBR126c | | Alias: | BYP1; CIF1; FDP1; GGS1; GLC6; TSS1; YBR0922 | | Classification: | known protein | 5422 Entries | Evi
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PUBMED
| | Feature Type: | CDS | | Features |  |
Blast-Simap
DNA VIEW
PROTEIN VIEW
| | Similarity: |
| | Functional Classification: | - METABOLISM
..C-compound and carbohydrate metabolism
....regulation of C-compound and carbohydrate metabolism
| 127 Entries | Evi
- METABOLISM
..C-compound and carbohydrate metabolism
....sugar, glucoside, polyol and carboxylate metabolism
......sugar, glucoside, polyol and carboxylate catabolism
| 79 Entries | Evi
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PUBMED
- METABOLISM
..C-compound and carbohydrate metabolism
....sugar, glucoside, polyol and carboxylate metabolism
......sugar, glucoside, polyol and carboxylate anabolism
| 35 Entries | Evi
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PUBMED
| | EC Number: | - 2.4.1.15: Transferases
..Glycosyltransferases
....Hexosyltransferases
......?,?-trehalose-phosphate synthase (UDP-forming)
| 3 Entries | Evi
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PUBMED
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InterPro:
| | | Localization: | TPS1 localization details | | Remarks: | level of accumulated trehalose does not always correlate with level of thermotoleranceeither partial repression by glucose or induction by galactoseessential for growth on glucose and fructose |
PUBMED
induced by heat, osmotic and oxidative stress |
PUBMED
stress induces recycling of glycogen and trehalose |
PUBMED
phosphorylated by cAMP-dependent protein kinasephosphorylated form is less active3-fold more active at 40 deg than at 30 deg, which may explain heat-induced rise of trehalose in cycloheximide | | Phenotypes: | Disruption: TPS1 details___
mutants accumulate free glucosemutant byp1-3 has a long lag phase after glucose addition, fails to have a cAMP pulse, and spores fail to germinate on glucosenull mutant arrests in glucose due to overloading glycolysis with sugar phosphates and depletion of cytoplasmic phosphateglucose regulation is absent in null mutanttps1 hxk2 double null mutant has high glucose-6-phosphate and high intracellular glucosenull mutants lack trehalose, T-6-P and phosphatase activitiesnull mutant loses ability to accumulate trehalose after heat shock or at stationary phase and has reduced level of thermotolerancetps1 mutant proliferating cells lose viability upon heat shock to 42 degtps1 mutant proliferating cells show increased viability upon 42 deg heat shock if the shock is followed by a brief stress at 52.5 degtps1 hxk2 double mutant has normal glycolytic metabolite levels and normal transient cAMP response to glucosemutants do not grow on glucose in pfk1 or pfk2 backgroundmutants do not grow on fructosebyp1-3 tps2delta double mutant shows elevated tre-6-P levels, improved growth and ethanol productionbyp1-3 tps2delta double mutant shows elevated tre-6-P levels during logarithmic growth on glucosebyp1-3 tps2delta double mutant arrests growth and ethanol production on glucose after four generationsnull mutant is unable to grow on glucose but grows on galactosenull mutants are more sensitive to hydrostatic pressure |
PUBMED
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Mating and sporulation defects
..Sporulation efficiency | 112 Entries Auxotrophies, carbon and nitrogen utilization defects
..Carbon utilization
....other carbon utilization defects | 27 Entries Cell morphology and organelle mutants
..Cell wall mutants
....Osmotic sensitivity (Osm) | 43 Entries |
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