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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
TAT1 Broad-specificity amino-acid permease 
Entry:YBR069c
Alias:VAP1; YBR0710; (TAP1)
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (50.1 %) ;  |  Homologs in   Hemiascomycota (92.1 %);  Basidiomycota (32.2 %);  Fungi (92.1 %);  Eukaryota (92.1 %);  Plants (20.2 %);  Mammalia (20.2 %);  Human (19.1 %);  Bacteria (26.7 %);  All except yeast (92.1 %)
  • strong similarity to other amino acid transport proteins
  • strong similarity to Gnp1p, Agp1p and Scm1p
Functional Classification:
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....cellular import | 150 Entries | Evi
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....amino acid/amino acid derivatives transport | 45 Entries | Evi | PUBMED
TC Class:
  • The Uni/Sym/Antiporters
    ..The Uni/Sym/Antiporters
    ....Amino Acid/Polyamine/Organocation (APC) Superfamily
    ......The Yeast Amino Acid Transporter (YAT) Subfamily | 18 Entries | Evi | PUBMED
InterPro:
Localization:  TAT1 localization details
  • bud
  • cell periphery
  • plasma membrane
  • cytoplasm
  • ER
Remarks:
  • amino acid-induced transcription of TAT1 is mediated by Ssy1p | PUBMED
    Phenotypes:  Disruption: TAT1 details
    • viable
    ___
    • null mutant is insensitive to 5-fluorotryptophan
    • null mutant and overexpression both confer resistance to FK506
    • null mutant is lethal only in tyrosine auxotrophs
    • Exhibits sensitivity at 5 generations when grown in synthetic complete medium. | Evi | PUBMED
    ___
    • Sensitivity to immunosuppressants
      ..FK506
      ....FK506 resistance | 3 Entries
    Overexpression:
    • overexpression confers resistance to FK506
    • overexpressing cells show medium (10 fold increased) phytosphingosine (PHS) resistance to growth inhibition and tryptophan utilization by PHS compared to TAT2 overexpression cells and wildtype cells | PUBMED
    • overexpressing cells show no resistance to stearylamine or sphingosine | PUBMED
    Click for larger Map
    Physical Features
    Coordinates:378430 - 376571 (C)
    Length:1860 nt
    Contig:chrII
    Exon Coordinates:378430 - 376571
    GC Content:41.8 %
    Protein Length:619 aa
    Isoelectric Point:7.85
    Molecular Weight:68758 Da
    Transmembrane Domains:Begin - End / Length (aa)
    99 - 121 / 23
    131 - 153 / 23
    166 - 188 / 23
    203 - 225 / 23
    232 - 254 / 23
    282 - 304 / 23
    325 - 342 / 18
    372 - 394 / 23
    422 - 441 / 20
    451 - 473 / 23
    494 - 516 / 23
    531 - 548 / 18
    12 TM- Domains
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: X76294
    EMBL: Z35938
    PIR: S45932
    UniProtKB: P38085
    NCBI: NP_009625
    Additional Links:
    CYGD Tables:
  • Classification of the Major Facilitator Superfamily
    • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
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