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(chrI - chrXVI,chrMito,2-micron)

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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
TIP1 Esterase 
Entry:YBR067c
Alias:YBR0622
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (36.2 %) ;  |  Homologs in   Hemiascomycota (92.5 %);  Basidiomycota (17.2 %);  Fungi (92.5 %);  Eukaryota (92.5 %);  Plants (19.1 %);  Mammalia (14.3 %);  Human (3.4 %);  Bacteria (19.7 %);  All except yeast (92.5 %)
  • strong similarity to TIR1 and TIR2 | PUBMED
  • not related to any known lipase or esterase | PUBMED
  • 100% identity to extracellular esterase from S. carlsbergensis over 22 N-terminal residues | PUBMED
Functional Classification:
InterPro:
Localization:  TIP1 localization details
  • extracellular
  • cell wall
  • cell periphery
  • ER
 TargetP: Secretory pathway  (RC = 1)
Remarks:
  • temperature shock induced protein of the Srp1/Tip1p family
  • can be released from cell wall by beta-1,3-glucanase
  • induced 6-8 fold with 2 hr of a 30 deg to 10 deg shift
  • Mw determined by MALDI-TOF mass spectrometry: 16944 | PUBMED
  • contains a ISQITDGQIQA element near the C-terminal that is also found in Yju1p
  • lacks the conserved pentapeptide Gly-X-Ser-X-Gly found in lipases and esterases, but contains related sequence 49Gly-X-Ser-Phe53 | PUBMED
  • secreted protein
  • mannoprotein
  • has 20% ala and 23% ser
  • has a hydrophobic C-terminal region
  • C-terminal region is more than 40% serine and threonine
  • has no N-glycosylation motifs but many possible O-glycosylation sites
  • C-terminal sequence suggests a GPI-anchor
  • has beta-1,6-glucose-containing side chains
Phenotypes:  Disruption: TIP1 details
  • viable
___
  • null mutant has normal growth and survival after exposure to freezing temperature
  • tir1 tir2 tip1 triple null mutants are viable
Click for larger Map
Physical Features
Coordinates:372732 - 372100 (C)
Length:633 nt
Contig:chrII
Exon Coordinates:372732 - 372100
GC Content:47.7 %
Protein Length:210 aa
Isoelectric Point:4.19
Molecular Weight:20727.5 Da
Mature Protein:20-210
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z35936
PIR: A40979
UniProtKB: P27654
NCBI: NP_009623
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
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