| Entry: | YBL016w |
| Alias: | DAC2; FAR2; YBL03.21; YBL0303 |
| Classification: | known protein | 5422 Entries | Evi
|
PUBMED
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| Feature Type: | CDS |
| Features |
 |
Blast-Simap
DNA VIEW
PROTEIN VIEW
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| Similarity: |
strong similarity to Kss1pserine/threonine protein kinase member of the MAP kinase familybelongs to the CDC2/CDC28 subfamily of ser/thr protein kinases |
| Functional Classification: | - CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM
..transmembrane signal transduction
| 43 Entries | Evi
|
PUBMED
- CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM
..cellular signalling
....enzyme mediated signal transduction
......protein kinase
........MAPKKK cascade
| 27 Entries | Evi
|
PUBMED
- INTERACTION WITH THE ENVIRONMENT
..cellular sensing and response to external stimulus
....chemoperception and response
......pheromone response, mating-type determination, sex-specific proteins
| 189 Entries | Evi
|
PUBMED
- PROTEIN FATE (folding, modification, destination)
..protein modification
....modification by phosphorylation, dephosphorylation, autophosphorylation
| 186 Entries | Evi
|
PUBMED
- CELL CYCLE AND DNA PROCESSING
..cell cycle
....mitotic cell cycle and cell cycle control
......cell cycle arrest
| 21 Entries | Evi
|
PUBMED
- REGULATION OF METABOLISM AND PROTEIN FUNCTION
..regulation of protein activity
....regulator of G-protein signalling
| 15 Entries | Evi
- PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
..protein binding
| 392 Entries | Evi
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PUBMED
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| EC Number: | - 2.7.1.-: Transferases
..Transferring Phosphorus-Containing Groups
....Phosphotransferases with an Alcohol Group as Acceptor
| 166 Entries
|
|
Pathway: |
| part of a conserved kinase cascade including Ste7p and Ste11p
| default mating pathway requires Axl1p, Fus1p, Fus2p, Fus3p, Pea2p, Rvs161p, Bni1p and Spa2p
| these proteins are also required for efficient cell fusion during chemotropic mating |
|
InterPro:
| |
| Localization: | FUS3 localization detailscytoplasmnucleusmitochondria |
| Remarks: | cannot be substituted by Kss1p for G1 arrest functioninactivation of catalytic site leads to hyperphosphorylationhyperphosphorylation of fus3gf is independent of Ste7pFUS3 dephosphorylated by Msg5pCLN2 overexpression represses Fus3p kinase activity, independently of Msg5p |
| Phenotypes: | Disruption: FUS3 details___
gain of function mutant fus3gf requires Ste7p and Ste11p for activitygain of function mutant fus3gf has higher autophosphorylation on tyrosine and increased sensitivity to upstream signalsnull mutation increases the transposition of genomic Ty1 elements 18- to 56-fold, but has little effect on the transposition of related Ty2 elements |
PUBMED
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| Suppression: | suppresses growth defect of gpa1 mutation |
