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MPact protein interaction

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About CYGD

MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
ACS1 Acetyl-CoA synthetase 
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Paralogs (54.2 %) ;  |  Homologs in   Hemiascomycota (98.6 %);  Basidiomycota (52.5 %);  Fungi (98.6 %);  Eukaryota (98.6 %);  Plants (46.2 %);  Mammalia (44.1 %);  Human (44 %);  Bacteria (48.1 %);  All except yeast (98.6 %)

    Functional Classification:
      ..C-compound and carbohydrate metabolism
      ....C-2 compound and organic acid metabolism
      ......C-2 compound and organic acid catabolism | 9 Entries | Evi | PUBMED
      ..C-compound and carbohydrate metabolism
      ....C-2 compound and organic acid metabolism
      ......C-2 compound and organic acid catabolism | 9 Entries | Evi | PUBMED
      ..metabolism of vitamins, cofactors, and prosthetic groups
      ....biosynthesis of vitamins, cofactors, and prosthetic groups | 110 Entries | Evi | PUBMED
    EC Number:
    • Ligases
      ..Forming Carbon-Sulfur Bonds
      ....Acid-Thiol Ligases
      ......acetate?CoA ligase | 2 Entries | Evi | PUBMED
    • acetate metabolism
    TC Class:
    • The unclassifiable, putative or spurios Transporters
      ..The Putative Uncharacterized Transporters
      ....The Putative Fatty Acid Transporter (FAT) Family
      ......The Putative Fatty Acid Transporter (FAT-1) Subfamily Type 1 | 4 Entries | Evi | PUBMED
    Localization:  ACS1 localization details
    • cytoplasm
    • nucleus
    • mitochondria
    • peroxisome
    • peroxisome
      ..peroxisomal matrix
    • may have two translational start sites
    • induced 19-fold at stationary phase
    • induction by acetate
    • Acs1p, but not Acs2p can use proprionate as a substrate
    • Km for Acs1p is about 30-fold lower than that for Acs2p
    Phenotypes:  Disruption: ACS1 details
    • viable
    • null mutant grows normally on ethanol
    • null mutant fails to grow on media with acetate as sole carbon source
    • null mutant has normal induction of Icl1p
    • mutants are hypersensitive to calcofluor white | PUBMED
    • mutants are hypersensitive to zymolyase | PUBMED
    • Cell morphology and organelle mutants
      ..Cell wall mutants
      ....Calcofluor white
      ......Calcofluor white sensitivity | 88 Entries
    Click for larger Map
    Physical Features
    Coordinates:45023 - 42882 (C)
    Length:2142 nt
    Exon Coordinates:45023 - 42882
    GC Content:45.4 %
    Protein Length:713 aa
    Isoelectric Point:6.15
    Molecular Weight:79141.1 Da
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: U12980
    EMBL: X66425
    EMBL: X76891
    PIR: S51967
    NCBI: NP_009347
    Additional Links:
    CYGD Pathways:
  • Metabolic and genetic control of gene expression
  • The role of MIG1 in metabolic functions
  • CYGD Tables:
  • The Yeast homologues of human disease-associated genes
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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