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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  I  II  III  IV  V  VI  VII
  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
TLC1  
Entry:RNA_TLC1
Feature Type:misc_RNA
Features
Similarity:
Paralogs ( %) ;  |  Homologs in   Hemiascomycota ( %);  Basidiomycota ( %);  Fungi ( %);  Eukaryota ( %);  Plants ( %);  Mammalia ( %);  Human ( %);  Bacteria ( %);  All except yeast ( %)
    Functional Classification:
    • CELL CYCLE AND DNA PROCESSING
      ..DNA processing
      ....DNA synthesis and replication | 138 Entries | Evi
    Remarks:
    • extension of lifespan in tlc1 mutants is dependent on SIR3 | PUBMED
    • telomerase RNA subunit
    • used as template to determine the telomere sequence
      Phenotypes:___
      • mutants have telomeres with a shorter steady-state length | PUBMED
      • in tlc1 mutants TG1-3 single-stranded DNA are generated on chromosomal and plasmid telomeres only during S-phase | PUBMED
      • tlc1 mutants show approximately 20% longer lifespan than wildtype cells | PUBMED
      • a hdf2 tcl1 double mutant dies after 10 generations | PUBMED
      ___
      • Nucleic acid metabolism defects
        ..DNA replication mutants
        ....other DNA replication mutants | 19 Entries
      Overexpression:
      • TLC1 overexpression suppresses telomeric silencing | PUBMED
      Click for larger Map
      Physical Features
      Coordinates:307587 - 308887 (W)
      Length:1301 nt
      Contig:chrII
      Retrieve Sequence: DNA
      Literature | References
      CYGD curated Lit.:PubMed
      PubMed:Search abstracts
      PubMed Central:Search full-text articles
      Sequence References:
      Additional Links:
      LinkOut:
    • SGD - Saccharomyces Genome Database
    • YGOB - Yeast Gene Order Browser
    • yMGV - yeast Microarray Global Viewer
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