| MfunGD provides a resource for annotated mouse proteins and their occurence in protein
networks. Protein function annotation is performed using the Functional Catalogue
(FunCat) annotation scheme,
which is a hierarchically structured classification system (Ruepp
et al., NAR, 2004). To provide up-to-date similarity search results and InterPro domain
analyses, the protein entries are interconnected with the
SIMAP database (Rattei
et al., NAR, 2006). The gene models are based on the RefSeq mouse cDNAs (Pruitt
et al., NAR, 2007) The work of our group is focussed on the annotation of biological systems.
Therefore, results from the Mammalian Protein-Protein Interaction Database (
MPPI,
(Pagel
et al., Bioinformatics, 2005 )) and the Comprehensive Resource of Mammalian Protein Complexes (CORUM, (Ruepp
et al., NAR, 2007)) are linked to the MfunGD dataset. Links to external resources are also
provided (e.g.
Refseq,
Uniprot,
UCSC Genome Browser). MfunGD is implemented
in
GenRE, a J2EE based component oriented multi-tier
architecture (Mewes
et al., NAR, 2006). |
