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Entry information

Protein complex ID:568
Last modified on:2008-08-22

Protein complex name and species

Name:

Nuclear pore complex

Organism:Rat

Subunits

Protein descriptionGene nameGene synonymsOrganismUniProt IDEntrez-ID
AladinAAASADRACALA, GL003Homo sapiensQ9NRG98086
Nuclear pore complex protein Nup107NUP107Homo sapiensP5774057122
Nuclear pore complex protein Nup133NUP133Homo sapiensQ8WUM055746
Nuclear pore complex protein Nup153Nup153Rattus norvegicusP4979125281
Nuclear pore complex protein Nup155Nup155Rattus norvegicusP37199117021
Nuclear pore complex protein Nup160NUP160KIAA0197, NUP120Homo sapiensQ1276923279
Nup188 proteinNup188Rattus norvegicusQ5RJY5366016
Nuclear pore complex protein Nup205NUP205C7orf14, KIAA0225Homo sapiensQ9262123165
Nuclear pore complex protein Nup214NUP214CAIN, CAN, KIAA0023Homo sapiensP356588021
Nucleoporin NUP53Nup35Nup53Rattus norvegicusQ68FY1295692
Nucleoporin Nup37NUP37Homo sapiensQ8NFH479023
Nucleoporin Nup43NUP43Homo sapiensQ8NFH3348995
Nucleoporin 50 kDaNup50Npap60Rattus norvegicusO0858725497
Nucleoporin p54Nup54Rattus norvegicusP7058253372
Nuclear pore glycoprotein p62Nup62Rattus norvegicusP1795565274
Nucleoporin NUP85NUP85NUP75, PCNT1Homo sapiensQ9BW2779902
Nuclear pore complex protein Nup88Nup88Nup84Rattus norvegicusO08658113929
Nuclear pore complex protein Nup93Nup93Rattus norvegicusQ66HC5291874
Nuclear pore complex protein Nup98-Nup96NUP98ADAR2Homo sapiensP529484928
Nucleoporin p58/p45Nupl1Rattus norvegicusP70581245922
Nucleoporin-like 2NUPL2CG1Homo sapiensO1550411097
Nuclear envelope pore membrane protein POM 121Pom121Nup121Rattus norvegicusP52591113975
Nuclear pore membrane glycoprotein 210Pom210Gp210Rattus norvegicusP1165458958
mRNA export factorRae1Mrnp41Rattus norvegicusQ3SWS8362281
E3 SUMO-protein ligase RanBP2RANBP2NUP358Homo sapiensP497925903
Protein SEC13 homologSEC13D3S1231E, SEC13L1, SEC13RHomo sapiensP557356396
Nucleoporin SEH1-likeSEH1LSEC13L, SEH1Homo sapiensQ96EE381929
Nucleoprotein TPRTPRHomo sapiensP122707175

Subunit comment

Since several proteins from rat were not available in the UniProt database at the time of annotation, the orthologous human proteins were used. In rat, the nuclear pore complex contains two different isoforms of NUPL1. Human isoform p45 has not yet been isolated. Isoforms of NUP98 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively.

Purification method

  • MI:0069- mass spectrometry studies of complexes
  • MI:0028- cosedimentation in solution

Functional charaterization

FunCatFunCat-EviReference
20 CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
20.01 transported compounds (substrates)
20.01.10 protein transport
lit16777596
20 CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
20.01 transported compounds (substrates)
20.01.21 RNA transport
exp11684705
20 CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
20.03 transport facilities
20.03.01 channel / pore class transport
20.03.01.05 nuclear pore forming protein
exp12196509
20 CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
20.09 transport routes
20.09.01 nuclear transport
lit16777596
70 SUBCELLULAR LOCALIZATION
70.10 nucleus
70.10.05 nuclear membrane
exp12196509

GO characterisation

GOGo description
GO:0015031protein transport
GO:0008565protein transporter activity
GO:0050658RNA transport
GO:0051033RNA transporter activity
GO:0051169nuclear transport
GO:0005635nuclear envelope

Comment

All trafficking of macromolecules between the cytoplasm and the nucleus occurs through nuclear pore complexes (NPCs), which are supramolecular assemblies at points of fusion between the inner and outer nuclear membranes. NPCs are composed of an eightfold symmetric spoke-ring complex, cytoplasmic fibers, and a nuclear basket.

Reference

PubMed= 12196509

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