Search Results for "SIRT1" - 309 interactions found in 40 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
9
24 IL1B decreases_expression of SIRT1
40 Resveratrol increases_activity of SIRT1
42 SIRT1 decreases_expression of NOS2 if SIRT1 is overexpressed
19008341 Diabetes mellitus, type I
12
43 IL1B decreases_expression of SIRT1
45 SIRT1 decreases_expression of NOS2 if SIRT1 is overexpressed
46 SIRT1 increases_activity of insulin secretion if SIRT1 is overexpressed in cytokine treated cells
19008341 Diabetes mellitus, type I
39
90 SIRT1 interacts (colocalizes) with RELA
91 Resveratrol increases_activity of SIRT1
93 SIRT1 decreases_activity of positive regulation of NF-kappaB transcription factor activity
95 SIRT1 decreases_activity of EP300 if SIRT1 is overexpressed
96 SIRT1 decreases_acetylation of RELA
15152190 Diabetes mellitus, type I
824
4790 SIRT1 decreases_acetylation of PPARGC1A
4791 SIRT1 increases_activity of PPARGC1A
4816 SIRT1 decreases_acetylation of PPARGC1B
4817 SIRT1 increases_activity of PPARGC1B
4818 SIRT1 is localized in nucleus
4869 SIRT1 increases_activity of PPARGC1A in skeletal muscle
4905 SIRT1 decreases_acetylation of CRTC2
4906 SIRT1 decreases_quantity of CRTC2 via ubiquitin-mediated degradation of CRTC2
4907 SIRT1 decreases_activity of gluconeogenesis
4908 Glucagon NOT affects_activity of SIRT1
4917 SIRT1 increases_activity of improved glucose tolerance in pancreas, in pancreatic islets
4918 SIRT1 increases_activity of insulin secretion in pancreas, in pancreatic islets
4919 SIRT1 decreases_expression of UCP2 in pancreas, in pancreatic islets
4920 SIRT1 decreases_expression of PRLR in pancreas, in pancreatic islets
4951 SIRT1 decreases_acetylation of NR1H
4952 SIRT1 increases_activity of NR1H
5076 SIRT1 interacts (colocalizes) with PPARG in adipose tissue, in mature adipocytes
5078 SIRT1 decreases_activity of PPARG in adipose tissue, in mature adipocytes
5080 SIRT1 increases_activity of fat reserve metabolic process in adipose tissue, in mature adipocytes; during food deprivation
5136 SRT1720 increases_activity of SIRT1
19770177 Diabetes mellitus, type II
Obesity
Insulin resistance
868
5146 SIRT1 NOT affects_quantity of Insulin in blood; on standard diet, if SIRT1 is overexpressed
5148 SIRT1 NOT affects_quantity of Glucose in blood; on standard diet, if SIRT1 is overexpressed
5149 SIRT1 NOT affects_activity of response to glucose on standard diet, if SIRT1 is overexpressed
5181 SIRT1 NOT affects_activity of response to insulin on standard diet, if SIRT1 is overexpressed
5182 SIRT1 increases_quantity of ADIPOQ in blood; on standard diet, if SIRT1 is overexpressed
5184 SIRT1 affects_activity of increased basal metabolism on standard diet, if SIRT1 is overexpressed
5185 SIRT1 decreases_activity of Insulin resistance if SIRT1 is overexpressed
5186 SIRT1 NOT affects_activity of increased basal metabolism on high-fat diet, if SIRT1 is overexpressed
5187 SIRT1 decreases_quantity of Insulin in blood; on high-fat diet, if SIRT1 is overexpressed
5188 SIRT1 increases_quantity of ADIPOQ in blood; on high-fat diet, if SIRT1 is overexpressed
5189 SIRT1 NOT affects_quantity of RETN in blood; on high-fat diet, if SIRT1 is overexpressed
5190 SIRT1 NOT affects_quantity of SERPINE1 in blood; on high-fat diet, if SIRT1 is overexpressed
5191 SIRT1 NOT affects_quantity of TNF in blood; on high-fat diet, if SIRT1 is overexpressed
5193 SIRT1 NOT affects_quantity of LEP in blood; on high-fat diet, if SIRT1 is overexpressed
5194 SIRT1 increases_expression of ADIPOQ in white adipose tissue; on standard diet, on high-fat diet, if SIRT1 is overexpressed
5197 SIRT1 increases_activity of AMPK in white adipose tissue, in liver, in skeletal muscle; on high-fat diet, if SIRT1 is overexpressed
5199 SIRT1 increases_expression of PPARA in liver; on high-fat diet, if SIRT1 is overexpressed
5201 SIRT1 increases_expression of CPT1A in liver; on high-fat diet, via increased PPAR-alpha expression, if SIRT1 is overexpressed
5202 SIRT1 increases_expression of ADIPOR2 in liver; on high-fat diet, via increased PPAR-alpha expression, if SIRT1 is overexpressed
5205 SIRT1 decreases_acetylation of FOXO1
5207 SIRT1 decreases_acetylation of FOXO1 in liver; if SIRT1 is overexpressed
5208 SIRT1 decreases_acetylation of PPARGC1A in skeletal muscle; if SIRT1 is overexpressed
13148 SIRT1 NOT affects_activity of abnormal body weight on standard diet, if SIRT1 is overexpressed
18840364 Diabetes mellitus, type II
Insulin resistance
897
5302 SRT1720 interacts (colocalizes) with SIRT1
5311 SRT1720 increases_activity of SIRT1
5314 SIRT1 decreases_activity of increased circulating insulin level in diet-induced obesity mice
5317 SIRT1 NOT affects_quantity of Insulin in non-insulin resistant chow-fed mice
5318 SIRT1 increases_activity of CS in gastrocnemius muscle
5320 SIRT1 decreases_quantity of Glucose in blood; in diabetic Lep ob/ob mice
5331 SIRT1 decreases_activity of Insulin resistance in adipose tissue, in skeletal muscle, in liver; in Zucker fa/fa rats
50433 SRT501 increases_activity of SIRT1
18046409 Diabetes mellitus, type II
Insulin resistance
904
5370 SIRT1 NOT affects_activity of abnormal body weight if SIRT1 is overexpressed
5373 SIRT1 NOT affects_quantity of LEP in blood; on standard diet, on high-fat diet, if SIRT1 is overexpressed
5374 SIRT1 NOT affects_quantity of ADIPOQ in blood; on standard diet, on high-fat diet, if SIRT1 is overexpressed
5375 SIRT1 affects_activity of increased food intake on high-fat diet, if SIRT1 is overexpressed
5376 SIRT1 affects_activity of increased energy expenditure on high-fat diet, if SIRT1 is overexpressed
5379 SIRT1 NOT affects_activity of energy homeostasis on high-fat diet, if SIRT1 is overexpressed
5381 SIRT1 affects_activity of Fatty liver disease, nonalcoholic after 19 weeks of high-fat diet, if SIRT1 is overexpressed
5382 SIRT1 affects_expression of SREBF1c in response to high-fat diet, if SIRT1 is overexpressed
5383 SIRT1 decreases_activity of Fatty liver disease, nonalcoholic
5388 SIRT1 NOT affects_expression of IL6 in liver; in response to high-fat diet, if SIRT1 is overexpressed
5389 SIRT1 NOT affects_expression of TNF in liver; in response to high-fat diet, if SIRT1 is overexpressed
5394 SIRT1 affects_activity of NF-kappaB complex if SIRT1 is overexpressed
5396 SIRT1 affects_expression of SOD2 on standard diet, on high-fat diet, if SIRT1 is overexpressed
5399 SIRT1 decreases_activity of inflammatory response if SIRT1 is overexpressed, via decreased NF-kappaB activity
13187 SIRT1 NOT affects_activity of increased energy expenditure on standard diet, if SIRT1 is overexpressed
13191 SIRT1 affects_expression of NRF1 on standard diet, on high-fat diet, if SIRT1 is overexpressed
13192 SIRT1 increases_activity of PPARGC1A on standard diet, on high-fat diet, if SIRT1 is overexpressed
13193 SIRT1 decreases_activity of response to oxidative stress if SIRT1 is overexpressed
18599449 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
906
5402 SirT1 ASO rat decreases_expression of SIRT1 in liver, in white adipose tissue, in brown adipose tissue
5426 SirT1 ASO rat NOT decreases_expression of SIRT1 in muscle
5427 SirT1 ASO rat NOT decreases_expression of SIRT1 in hypothalamus
5428 SIRT1 affects_quantity of Fatty acid in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5433 SIRT1 affects_quantity of LEP in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5436 SIRT1 affects_quantity of ADIPOQ in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5438 SIRT1 affects_expression of PPARG in epididymal white adipose tissue; both splice variants PPAR-gamma1 and PPAR-gamma2, if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5443 SIRT1 affects_quantity of CEBPA in adipose tissue; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5445 SIRT1 NOT affects_quantity of Triacylglycerol in blood, in liver; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5446 SIRT1 affects_quantity of (R)-3-Hydroxybutanoate in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5449 SIRT1 affects_quantity of Cholesterol in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5452 SIRT1 affects_expression of NR1H3 if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5454 SIRT1 affects_expression of SCARB1 if SIRT1 is knocked down in liver and white adipose tissue of diabetic rats
5457 SIRT1 affects_expression of CYP7A1 if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5458 SIRT1 affects_activity of bile acid biosynthetic process if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5460 SIRT1 affects_expression of LDLR if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5462 SIRT1 NOT affects_expression of ABCG8 if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5463 SIRT1 NOT affects_expression of SREBF2 if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5465 SIRT1 NOT affects_expression of HMGCR if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5469 SIRT1 affects_activity of increased insulin sensitivity in liver; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5472 SIRT1 affects_acetylation of STAT3 if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5475 SIRT1 affects_phosphorylation of STAT3 if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5478 SIRT1 affects_acetylation of FOXO1 if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5480 SIRT1 affects_acetylation of PPARGC1A if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5481 SIRT1 affects_expression of PCK1 if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5482 SIRT1 affects_expression of FBP1 if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5484 SIRT1 affects_expression of G6PC if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
5486 SIRT1 affects_activity of gluconeogenesis if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
19549853 Diabetes mellitus, type II
Insulin resistance
918
5660 prolonged fasting increases_quantity of SIRT1 in liver
5662 SIRT1 decreases_acetylation of CRTC2 during prolonged fasting
5667 SIRT1 decreases_quantity of CRTC2 via ubiquitin-dependent degradation by COP1 during prolonged fasting
5669 SIRT1 increases_activity of FOXO1 during prolonged fasting
5673 SIRT1 affects_activity of CRTC2
5727 SIRT1 affects_quantity of Glucose
5728 SIRT1 decreases_activity of CRTC2
18849969 Diabetes mellitus, type II
Insulin resistance
947
5731 SIRT1 affects_activity of peroxisome proliferator activated receptor alpha signaling pathway in liver; if SIRT1 is knocked out in liver
5742 SIRT1 affects_expression of ACADM in liver; on chow diet, if SIRT1 is knocked out in liver
5746 SIRT1 affects_expression of EHHADH in liver; on chow diet, if SIRT1 is knocked out in liver
5747 SIRT1 affects_expression of ACOX1 in liver; on chow diet, if SIRT1 is knocked out in liver
5754 SIRT1 affects_expression of CD36 in liver; on chow diet, if SIRT1 is knocked out in liver
5755 SIRT1 affects_expression of Cyp4A10 in liver; on chow diet, if SIRT1 is knocked out in liver
5756 SIRT1 affects_expression of Cyp4A14 in liver; on chow diet, if SIRT1 is knocked out in liver
5758 SIRT1 affects_expression of THRSP in liver; on chow diet, if SIRT1 is knocked out in liver
5759 SIRT1 affects_expression of CPT1A in liver; after overnight fasting, if SIRT1 is knocked out in liver
5763 SIRT1 affects_expression of ACOX1 in liver; after overnight fasting, if SIRT1 is knocked out in liver
5764 SIRT1 affects_expression of CD36 in liver; after overnight fasting, if SIRT1 is knocked out in liver
5765 SIRT1 affects_expression of Cyp4A14 in liver; after overnight fasting, if SIRT1 is knocked out in liver
5766 SIRT1 affects_expression of CYCS in liver; after overnight fasting, if SIRT1 is knocked out in liver
5768 SIRT1 affects_expression of PPARGC1A in liver; after overnight fasting, if SIRT1 is knocked out in liver
5777 SIRT1 affects_activity of regulation of peroxisome proliferator activated receptor signaling pathway in liver
5780 SIRT1 increases_activity of PPARA
5787 SIRT1 interacts (colocalizes) with PPARA
5788 SIRT1 increases_activity of PPARGC1A
5793 SIRT1 affects_activity of Obesity if SIRT1 is knocked out in liver
5796 SIRT1 affects_expression of CPT1A in liver; on high-fat diet, if SIRT1 is knocked out in liver
5804 SIRT1 affects_expression of CPT2 in liver; on high-fat diet, if SIRT1 is knocked out in liver
5805 SIRT1 affects_expression of ACAD in liver; on high-fat diet, if SIRT1 is knocked out in liver
5806 SIRT1 decreases_expression of ACOX1 in liver; on high-fat diet, if SIRT1 is knocked out in liver
5807 SIRT1 affects_expression of CD36 in liver; on high-fat diet, if SIRT1 is knocked out in liver
5808 SIRT1 affects_expression of Cyp4A14 in liver; on high-fat diet, if SIRT1 is knocked out in liver
5809 SIRT1 affects_expression of Cyp4A10 in liver; on high-fat diet, if SIRT1 is knocked out in liver
5811 SIRT1 affects_activity of fatty acid beta-oxidation in liver; on high-fat diet, if SIRT1 is knocked out in liver
5820 SIRT1 affects_expression of CYCS in liver; on high-fat diet, if SIRT1 is knocked out in liver
5821 SIRT1 affects_expression of COX4 in liver; on high-fat diet, if SIRT1 is knocked out in liver
5843 SIRT1 affects_expression of COX5B in liver; on high-fat diet, if SIRT1 is knocked out in liver
5849 SIRT1 affects_activity of oxidative phosphorylation in liver; on high-fat diet, if SIRT1 is knocked out in liver
5850 SIRT1 affects_expression of PPARGC1A in liver; on high-fat diet, if SIRT1 is knocked out in liver
5851 SIRT1 affects_expression of GPAM in liver; on high-fat diet, if SIRT1 is knocked out in liver
5852 SIRT1 affects_expression of DGAT1 in liver; on high-fat diet, if SIRT1 is knocked out in liver
5853 SIRT1 affects_expression of DGAT2 in liver; on high-fat diet, if SIRT1 is knocked out in liver
5854 SIRT1 affects_activity of triglyceride biosynthetic process in liver; on high-fat diet, if SIRT1 is knocked out in liver
5855 SIRT1 affects_activity of CYP7A1 in liver; on high-fat diet, if SIRT1 is knocked out in liver
5857 SIRT1 affects_activity of liver inflammation in liver; on high-fat diet, if SIRT1 is knocked out in liver
5858 SIRT1 affects_activity of response to endoplasmic reticulum stress in liver; on high-fat diet, if SIRT1 is knocked out in liver
5862 SIRT1 affects_quantity of EIF2S1-phos in liver; if SIRT1 is knocked out in liver
5876 SIRT1 affects_quantity of JUN-phos in liver; if SIRT1 is knocked out in liver
5884 SIRT1 affects_quantity of CCL3 in liver; if SIRT1 is knocked out in liver
5885 SIRT1 affects_quantity of VCAM1 in liver; if SIRT1 is knocked out in liver
5887 SIRT1 affects_quantity of SAA1 in liver; if SIRT1 is knocked out in liver
5888 SIRT1 affects_quantity of CXCL10 in liver; if SIRT1 is knocked out in liver
5889 SIRT1 affects_quantity of TNF in liver; if SIRT1 is knocked out in liver
5890 SIRT1 affects_quantity of IL1B in liver; if SIRT1 is knocked out in liver
5891 SIRT1 affects_quantity of AKT1-phosSer473 in liver; on high-fat diet, if SIRT1 is knocked out in liver
13195 SIRT1 affects_activity of fatty acid beta-oxidation in liver; via PPARA
13196 SIRT1 affects_quantity of Lipid in liver; if SIRT1 is knocked out in liver
13197 SIRT1 affects_quantity of Fatty acid in blood; if SIRT1 is knocked out in liver
13198 SIRT1 affects_quantity of (R)-3-Hydroxybutanoate in blood; if SIRT1 is knocked out in liver
19356714 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
1,007
6284 Alzheimer disease decreases_expression of SIRT1 in the parietal cortex of AD patients, but not in the cerebellum
6286 SIRT1 affects_quantity of Amyloid beta peptide in cerebral cortex
6287 SIRT1 affects_quantity of MAPT in cerebral cortex
29672 mild cognitive impairment NOT decreases_expression of SIRT1
19104446 Alzheimer disease
1,023
6377 SIRT1 decreases_quantity of amyloid beta deposits (microglia-dependent amyloid beta toxicity)
6418 SIRT1 affects_activity of NF-kappaB complex
6420 Resveratrol increases_activity of SIRT1
16183991 Alzheimer disease
1,179
13352 NOS2 affects_expression of SIRT1
20532036 Diabetes mellitus, type II
Obesity
Insulin resistance
1,759
13222 SIRT1 affects_activity of NEUROG2 during murine embryonic caudal neural tube development at E9.5, but not at E12.5
21169561 Neurological
2,006
15911 SIRT1 affects_activity of amyloidosis in cell culture studies in vitro and in transgenic mouse models of Alzheimer's disease
15914 SIRT1 increases_activity of ADAM10
21349442 Alzheimer disease
2,007
15918 response to stress affects_expression of SIRT1
15922 phosphorylation affects_activity of SIRT1
15924 SIRT1 decreases_acetylation of HSF1 if SIRT1 is phosphorylated.
15927 SIRT1 increases_activity of HSF1 if SIRT1 is phosphorylated.
15942 SIRT1 affects_activity of deacetylase activity
15943 SIRT1 increases_expression of Alpha-secretase
21121893 Alzheimer disease
2,008
15946 calorie restriction increases_expression of SIRT1 in the brain; of about 10-month-old Tg2576 mice
15970 SIRT1 increases_activity of Alpha-secretase
15971 SIRT1 decreases_quantity of Amyloid beta peptide
16751189 Alzheimer disease
4,000
41068 Obesity decreases_expression of SIRT1 in subcutaneous adipose tissue; in monozygotic twins discordant for obesity
18336063 Diabetes mellitus, type II
Obesity
Insulin resistance
4,348
44453 Rotenone increases_expression of SIRT1 at concentrations of 12.5 and 25 nmol/L rotenone
23930106 Diabetes mellitus, type II
Insulin resistance
4,370
44566 Melatonin increases_expression of SIRT1
19650880 Diabetes mellitus, type II
Insulin resistance
5,061
49769 mir-128-2 decreases_quantity of SIRT1
23990020 Metabolic
Cardiovascular disease
5,152
50404 Resveratrol increases_activity of SIRT1 in kidney; in db/db mice
23090186 Diabetes mellitus, type II
Insulin resistance
Nephropathy, diabetic
5,241
51091 SIRT1 increases_activity of PPARGC1A via deacetylation
51096 NAD+ increases_activity of SIRT1
51097 SIRT1 affects_activity of lipid catabolic process in white adipose tissue
51098 SIRT1 affects_activity of insulin secretion in pancreas, in pancreatic beta cells
51099 SIRT1 affects_activity of ACSS1
51101 SIRT1 affects_activity of ACSS2
51102 SIRT1 affects_activity of circadian rhythm
51104 SIRT1 affects_activity of response to heat
51105 SIRT1 affects_activity of cellular response to DNA damage stimulus
51107 SIRT1 affects_activity of response to hypoxia
51108 Resveratrol increases_activity of SIRT1
51115 SIRT1 increases_expression of PCK1 via PPARGC1A
51118 SIRT1 increases_expression of G6PC via PPARGC1A
51121 feeding affects_quantity of SIRT1
20005308 Diabetes mellitus, type II
Insulin resistance
5,291
51752 SIRT1 increases_expression of PPARGC1A in skeletal muscle
19553684 Diabetes mellitus, type II
Insulin resistance
6,212
58878 spermatogonial stem cell decreases_expression of SIRT1 in both differentiating and aging spermatogonial stem cells
58881 Rapamycin increases_expression of SIRT1 in both differentiating and aging spermatogonial stem cells (SSCs)
22729928 Metabolic
6,301
60069 Panobinostat decreases_activity of SIRT1
60088 Peripheral T-cell leukemia / lymphoma increases_expression of SIRT1 Pattern of staining: Nuclear.
60119 SIRT1 decreases_acetylation of AKT1
60139 SIRT1 increases_activity of AKT1 via promoting phosphatidylinositol (3,4,5)-triphosphate binding to Akt.
60156 Vorinostat decreases_activity of SIRT1 of SIRT1 mRNA and Sirt1 deacetylase activity.
60191 Angioimmunoblastic T-Cell lymphoma increases_expression of SIRT1
25674239 Cancer
Cutaneous T-cell lymphoma
Peripheral T-cell leukemia / lymphoma
Angioimmunoblastic T-Cell lymphoma
6,302
60205 Tris(2-chloroethyl)phosphate increases_expression of SIRT1 in L02 and HepG2 cells; upregulated mRNA and protein levels of SIRT1
60209 SIRT1 NOT affects_activity of PI3K/AKT/TOR signaling in L02 and HepG2 cells
60210 EX-527 decreases_activity of SIRT1 in L02 and HepG2 cells
60211 SIRT1 increases_activity of PTEN/PI3K/Akt signaling if SIRT1 is overexpressed, resulting in a protection of the cells from apoptosis.
60212 SIRT1 decreases_activity of TOR signaling in mouse embryonic fibroblasts and HeLa cells; if SIRT1 is overexpressed, via TSC1-TSC2 complex.
60213 SIRT1 decreases_activity of cell proliferation in vitro and tumor formation in colon cancer
60219 Resveratrol increases_activity of SIRT1 resulting in an inhibition of cell growth by inducing cell cycle arrest.
60350 SIRT1 increases_activity of mitotic entry of liver cells; if SIRT1 is overexpressed.
60351 SIRT1 increases_activity of cell growth if SIRT1 is overexpressed.
60352 SIRT1 increases_activity of cell proliferation if SIRT1 is overexpressed.
60353 SIRT1 decreases_activity of apoptotic process if SIRT1 is overexpressed through activation of the PTEN/PI3K/Akt pathway.
60354 SIRT1 affects_activity of TSC1-TSC2 complex in mouse embryonic fibroblasts and HeLa cells; if SIRT1 is overexpressed, resulting in a negative regulation the mTOR pathway.
60357 SIRT1 decreases_activity of cell growth by inducing cell cycle arrest.
60358 SIRT1 increases_activity of cell cycle arrest
60359 SIRT1 decreases_activity of Breast cancer reducing tumor formation in a breast cancer model.
26378621 Breast cancer
6,303
59024 caloric restriction diet increases_activity of SIRT1 concerning mRNA expression.
26135885 Metabolic
6,387
61567 SIRT1 is localized in nucleus
61617 NAD+ affects_activity of SIRT1
61621 SIRT1 interacts (colocalizes) with CLOCK-BMAL1 complex
61624 exercise increases_activity of SIRT1
61625 fasting increases_activity of SIRT1
61626 caloric restriction increases_activity of SIRT1
61630 SIRT1 affects_activity of circadian clock
61631 SIRT1 increases_quantity of O-Acetyl-ADP-ribose
61632 SIRT1 increases_quantity of Nicotinamide
61635 SIRT1 affects_activity of TP53
61641 SIRT1 affects_activity of PPARGC1A
61642 SIRT1 affects_activity of HIF1A
61643 SIRT1 affects_activity of EPAS1
61644 SIRT1 affects_activity of NR1H
61645 SIRT1 affects_activity of GPR85
61646 SIRT1 affects_activity of NR1H4
61647 SIRT1 affects_activity of NFKB1
61648 SIRT1 affects_activity of PER2
61649 SIRT1 affects_activity of CRTC2
61650 SIRT1 affects_activity of E2F1
61651 SIRT1 affects_activity of XRCC6
61652 Resveratrol increases_activity of SIRT1 depending on a functional AMPK.
61653 Hydroxytyrosol increases_expression of SIRT1
61654 SIRT1 interacts (colocalizes) with FOXO
61655 SIRT1 decreases_acetylation of FOXO
61656 SIRT1 decreases_acetylation of ATG5
61657 SIRT1 decreases_acetylation of ATG7
61658 SIRT1 decreases_acetylation of GABARAPL
61674 AMPK affects_activity of SIRT1 via modifying the NAD+/NADH ratio.
61676 SIRT1 affects_activity of STK11
61677 SIRT1 decreases_expression of MTOR if SIRT1 is overexpressed, concerning the mTOR protein level.
61679 SIRT1 decreases_activity of MTOR if SIRT1 is overexpressed.
61680 SIRT1 decreases_activity of TOR signaling if SIRT1 is overexpressed.
25955819 Metabolic
6,456
61184 SIRT1 decreases_activity of CRTC2 via deacetylation
61187 Metformin increases_activity of SIRT1
22117616 Diabetes mellitus, type II
Cancer
Insulin resistance
-->