Search Results for "PRKN" - 320 interactions found in 67 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
8
20 LRRK2 interacts (colocalizes) with PRKN
16352719 Parkinson disease
62
1008 PRKN decreases_activity of neuron death in substantia nigra
15576511 Parkinson disease 2, autosomal recessive juvenile
Parkinson disease
142
510 PRKN is localized in aggresome if PARK2 is overexpressed
16805805 Parkinson disease
147
531 PRKN interacts (colocalizes) with PINK1
536 PRKN NOT interacts (colocalizes) with PINK1-p.H271Q
537 PRKN NOT interacts (colocalizes) with PINK1-p.G309D
538 PRKN NOT interacts (colocalizes) with PINK1-p.E417G
539 PRKN decreases_ubiquitination/sumoylation of PINK1
540 PRKN NOT decreases_ubiquitination/sumoylation of PINK1-p.H271Q
541 PRKN NOT decreases_ubiquitination/sumoylation of PINK1-p.G309D
542 PRKN NOT decreases_ubiquitination/sumoylation of PINK1-p.E417G
9363 PRKN increases_quantity of PINK1 by inhibiting its ubiquitin-mediated proteasomal degradation
9364 PRKN NOT increases_quantity of PINK1-p.H271Q by inhibiting its ubiquitin-mediated proteasomal degradation
9365 PRKN NOT increases_quantity of PINK1-p.G309D by inhibiting its ubiquitin-mediated proteasomal degradation
9366 PRKN NOT increases_quantity of PINK1-p.E417G by inhibiting its ubiquitin-mediated proteasomal degradation
9367 PRKN affects_activity of proteasome-mediated ubiquitin-dependent protein catabolic process
19358826 Parkinson disease
148
548 PPD complex increases_ubiquitination/sumoylation of PRKN
558 PINK1 decreases_quantity of PRKN via ubiquitin-mediated proteasomal degradation
561 PINK1 increases_ubiquitination/sumoylation of PRKN
563 PINK1-p.G309D NOT decreases_quantity of PRKN via ubiquitin-mediated proteasomal degradation
565 PINK1-p.G309D NOT increases_ubiquitination/sumoylation of PRKN
19229105 Parkinson disease
152
571 PINK1 increases_transport of PRKN into mitochondria; by phosphorylation of PARK2
4052 PINK1 increases_phosphorylation of PRKN
18957282 Parkinson disease
154
577 PRKN is localized in mitochondrion in proliferating cells
578 PRKN is localized in cytoplasm in differentiated or quiescent cells
590 PRKN interacts (colocalizes) with TFAM in mitochondria
9354 PRKN increases_activity of TFAM in mitochondria; thus increasing transcription activity in mitochondria
16449237 Parkinson disease
156
2626 PRKN decreases_activity of neuron death if cell death has been induced by loss of PINK1
2653 PRKN affects_activity of PINK1
19279012 Parkinson disease
242
1014 MAPT-p.VLW increases_expression of PRKN
19057915 Parkinson disease
403
1731 PRKN interacts (colocalizes) with microtubule
1734 PRKN interacts (colocalizes) with TUBB
1736 PRKN interacts (colocalizes) with TUBA
1737 PRKN interacts (colocalizes) with Alpha/beta-tubulin complex
1743 PRKN increases_ubiquitination/sumoylation of TUBB
1744 PRKN increases_ubiquitination/sumoylation of TUBA
12716939 Parkinson disease
405
1738 PRKN interacts (colocalizes) with TUBB
1739 PRKN interacts (colocalizes) with TUBA
1741 PRKN increases_ubiquitination/sumoylation of TUBB
1742 PRKN increases_ubiquitination/sumoylation of TUBA
1759 PRKN decreases_quantity of TUBB via ubiquitin-mediated proteasomal degradation
1760 PRKN decreases_quantity of TUBA via ubiquitin-mediated proteasomal degradation
12716939 Parkinson disease
466
4007 PRKN decreases_activity of neuron death
19684592 Parkinson disease
499
2418 PRKN is localized in cytoplasm
2430 PRKN is localized in mitochondrion
2431 CCCP increases_transport of PRKN into mitochondria
2432 mitochondrial depolarization increases_transport of PRKN into mitochondria
2433 PRKN increases_activity of autophagy of mitochondrion
2434 PRKN interacts (colocalizes) with MAP1LC3A after CCCP treatment
2556 mitochondrial depolarization increases_transport of PRKN into mitochondria
9829 PRKN decreases_activity of abnormal mitochondrial physiology by promoting autophagic degradation of mitochondria
19029340 Parkinson disease
500
2460 PRKN affects_activity of mitochondrial fragmentation involved in apoptotic process which has been induced by PINK1 knockdown
2695 PRKN affects_activity of PINK1
17989306 Parkinson disease
517
2558 CCCP increases_transport of PRKN into mitochondria
2559 FCCP increases_transport of PRKN into mitochondria
2562 PINK1 increases_transport of PRKN into mitochondria; after CCCP treatment
2563 PARK7 NOT affects transport of PRKN into mitochondria; after CCCP treatment
2572 PINK1-p.W437X NOT increases_transport of PRKN into mitochondria
2574 PINK1-p.L347P NOT increases_transport of PRKN into mitochondria
2579 PRKN interacts (colocalizes) with PINK1 in mitochondria
2580 PRKN NOT affects_ubiquitination/sumoylation of PINK1
2582 PRKN NOT affects_quantity of PINK1 via ubiquitin-mediated proteasomal degradation
2584 PINK1 increases_transport of PRKN into mitochondria; if PINK1 is overexpressed
9824 PRKN decreases_activity of abnormal mitochondrial physiology
45616 PRKN increases_activity of autophagy of mitochondrion together with Pink1
19966284 Parkinson disease
543
2744 CCCP increases_transport of PRKN into mitochondria
2785 PRKN increases_activity of autophagy of mitochondrion if Parkin is localized in mitochondria
2824 PINK1 affects transport of PRKN into mitochondria; after CCCP treatment
2850 PRKN increases_ubiquitination/sumoylation of VDAC1 after CCCP treatment
2857 VDAC1 affects transport of PRKN into mitochondria; after CCCP treatment
2859 TRAP1 NOT affects transport of PRKN into mitochondria; after CCCP treatment
20098416 Parkinson disease
558
2899 PRKN affects_activity of Parkinson disease 2, autosomal recessive juvenile
2900 PRKN increases_quantity of alpha-synuclein inclusion body
2999 PRKN is localized in alpha-synuclein inclusion body of the substantia nigra
12000718 Dementia, Lewy body
Parkinson disease 2, autosomal recessive juvenile
Parkinson disease
560
2902 PARK7 NOT interacts (colocalizes) with PRKN
2903 PARK7-p.L166P interacts (colocalizes) with PRKN
2909 PRKN increases_ubiquitination/sumoylation of PARK7-p.L166P
2911 PRKN NOT increases_ubiquitination/sumoylation of PARK7
2913 PRKN NOT decreases_quantity of PARK7-p.L166P via ubiquitin-mediated proteasomal degradation
2915 PRKN NOT decreases_quantity of PARK7 via ubiquitin-mediated proteasomal degradation
2922 UBE2N interacts (colocalizes) with PRKN
2923 PRKN interacts (colocalizes) with UBE2G2
2928 PRKN interacts (colocalizes) with UBE2H
2929 PRKN NOT interacts (colocalizes) with UBE2D1
2939 PRKN increases_activity of protein K63-linked ubiquitination of PARK7-L166P , together with UBC13-UEV1a complex
2940 PRKN increases_ubiquitination/sumoylation of PARK7-p.L166P via K63-linked ubiquitin chains
2942 PRKN is localized in aggresome after treatment with proteasome inhibitor MG132
2944 PRKN increases_transport of PARK7-p.L166P into aggresome
2945 PRKN NOT increases_transport of PARK7 into aggresome
17846173 Parkinson disease
566
2953 PRKN NOT affects_quantity of PARK7-p.L166P
2954 PRKN increases_transport of PARK7-p.L166P into aggresome
17846173 Parkinson disease
710
3931 PRKN interacts (colocalizes) with CTNNB1
3933 PRKN decreases_quantity of CTNNB1
3950 PRKN affects_activity of canonical Wnt signaling pathway
3974 PRKN decreases_quantity of CTNNB1
19591802 Parkinson disease
715
3975 PRKN decreases_quantity of CTNNB1 in ventral midbrain dopaminergic neurons
3979 PRKN NOT affects_expression of CTNNB1 in ventral midbrain dopaminergic neurons
3985 PRKN affects_activity of canonical Wnt signaling pathway in ventral midbrain dopaminergic neurons
3987 PRKN decreases_quantity of CTNNB1 in ventral midbrain dopaminergic neurons
3988 PRKN decreases_activity of neuron death in ventral midbrain dopaminergic neurons
19591802 Parkinson disease
720
4058 PRKN affects_activity of LRRK2
19692353 Parkinson disease
721
4065 PRKN decreases_activity of neuron death induced by LRRK2-p.G2019S mutant
4066 PRKN decreases_activity of LRRK2-p.G2019S
19741132 Parkinson disease
785
4397 PRKN interacts (colocalizes) with LIMK1 also in the presence of CHIP
4398 PRKN interacts (colocalizes) with LIMK2
4414 PRKN interacts (colocalizes) with FBXW7
4417 HSP70 interacts (colocalizes) with PRKN
4426 PRKN increases_ubiquitination/sumoylation of LIMK1 in vitro or in BE(2)-M17 cells, but not in HEK293 cells
4431 PRKN decreases_activity of LIMK1 in a cell type-dependent manner
4443 PRKN decreases_activity of actin filament polymerization through ubiquitination of LIMK1
4446 PRKN increases_activity of actin filament depolymerization through ubiquitination of LIMK1
4455 LIMK1 NOT increases_phosphorylation of PRKN
4456 Protein kinase A increases_phosphorylation of PRKN
4457 PRKN increases_ubiquitination/sumoylation of PRKN
4459 LIMK1 decreases_activity of PRKN
4462 LIMK1 decreases_ubiquitination/sumoylation of PRKN
17512523 Parkinson disease
823
4757 PRKN interacts (colocalizes) with UBE2L3
4758 PRKN interacts (colocalizes) with UBE2L6
4759 PRKN NOT interacts (colocalizes) with UBE2B
4760 PRKN NOT interacts (colocalizes) with CDC34
4761 PRKN NOT interacts (colocalizes) with UBE2D2
4762 PRKN NOT interacts (colocalizes) with UBE2D1
4763 PRKN NOT interacts (colocalizes) with UBE2D3
4764 PRKN NOT interacts (colocalizes) with UBE2E1
4765 PRKN increases_activity of protein ubiquitination
10888878 Parkinson disease 2, autosomal recessive juvenile
Parkinson disease
825
4774 PRKN is localized in alpha-synuclein inclusion body in brainstem
4776 PRKN interacts (colocalizes) with UBE2L3 in brainstem
4779 PRKN increases_ubiquitination/sumoylation of SNCA
11431533 Parkinson disease
867
5210 GGEL interacts (colocalizes) with PRKN in UPP (ubiquitin-immunopositive, insoluble protein particles)
15132984 Alzheimer disease
Huntington disease
874
5158 PRKN NOT interacts (colocalizes) with PSMD5
5160 PRKN NOT interacts (colocalizes) with Epsin
5161 PRKN interacts (colocalizes) with EPS15
16862145 Parkinson disease
876
5163 PRKN interacts (colocalizes) with EPS15
16862145 Parkinson disease
878
5169 PRKN interacts (colocalizes) with EPS15
5172 PRKN affects_activity of epidermal growth factor receptor signaling pathway
16862145 Parkinson disease
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