Search Results for PPARGC1A - 665 interactions found in 140 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
459
2039 STK11 affects_expression of PPARGC1A in liver
2041 STK11 affects_quantity of PPARGC1A in fasting mice
16308421 Diabetes mellitus, type II
Peutz-Jeghers syndrome
Insulin resistance
598
3199 high-phytoestrogen soy-based diet increases_expression of PPARGC1A
18420492 Diabetes mellitus, type II
Obesity
Insulin resistance
787
4403 PPARGC1A increases_quantity of LPIN1 if PPARGC1A is overexpressed
4499 LPIN1 interacts (colocalizes) with PPARGC1A
4500 LPIN1 increases_activity of PPARGC1A
13084 PPARGC1A affects_expression of LPIN1
16950137 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
824
4788 PPARA interacts (colocalizes) with PPARGC1A
4790 SIRT1 decreases_acetylation of PPARGC1A
4791 SIRT1 increases_activity of PPARGC1A
4792 KAT2A increases_acetylation of PPARGC1A
4793 KAT2A decreases_activity of PPARGC1A
4794 AMPK increases_phosphorylation of PPARGC1A in skeletal muscle
4795 p38 MAPK increases_phosphorylation of PPARGC1A in skeletal muscle
4797 AMPK increases_quantity of PPARGC1A in skeletal muscle; via decreased degradation of PPARGC1A
4799 p38 MAPK increases_quantity of PPARGC1A in skeletal muscle; via decreased degradation of PPARGC1A
4800 AKT1 increases_phosphorylation of PPARGC1A in liver
4802 AKT1 decreases_quantity of PPARGC1A in liver; via increased degradation of PPARGC1A
4803 PRMT1 increases_methylation of PPARGC1A at several Arg residues
4804 PRMT1 increases_activity of PPARGC1A
4805 PPARGC1A affects_activity of mRNA transcription via regulation of a transcription factor
4812 PPARGC1A interacts (colocalizes) with KAT2A
4840 fasting increases_expression of PPARGC1A in liver
4841 PPARGC1A affects_activity of gluconeogenesis in liver
4843 PPARGC1A affects_activity of fatty acid beta-oxidation in liver
4844 PPARGC1A increases_activity of gluconeogenesis in liver; if PPARGC1A is overexpressed
4850 CREB1 increases_activity of PPARGC1A in liver
4852 PPARGC1A increases_activity of FOXO1 in liver
4854 PPARGC1A increases_activity of NR3C1 in liver
4855 PPARGC1A increases_activity of HNF4A in liver
4862 AKT1 increases_phosphorylation of PPARGC1A in liver
4864 AKT1 decreases_quantity of PPARGC1A in liver; via increased degradation of PPARGC1A
4867 AKT1 decreases_activity of PPARGC1A in liver
4869 SIRT1 increases_activity of PPARGC1A in skeletal muscle
4870 KAT2A decreases_activity of PPARGC1A in skeletal muscle
4871 PPARGC1A increases_activity of fatty acid beta-oxidation in skeletal muscle
4903 CRTC2 increases_expression of PPARGC1A
4904 LPIN1 increases_expression of PPARGC1A
4909 fasting increases_expression of PPARGC1A in pancreas, in pancreatic islets
4910 Diabetes mellitus, type II increases_expression of PPARGC1A in pancreas, in pancreatic islets
4911 PPARGC1A decreases_expression of SLC2A2 in pancreas, in pancreatic islets
4912 PPARGC1A decreases_expression of GCK in pancreas, in pancreatic islets
4913 hyperlipidemia affects_expression of PPARGC1A in pancreas, in pancreatic islets
4914 hyperglycemia affects_expression of PPARGC1A in pancreas, in pancreatic islets
4915 Glucagon-like peptide 1 increases_expression of PPARGC1A in pancreas, in pancreatic islets
4916 PPARGC1A decreases_activity of detection of glucose in pancreas, in pancreatic islets
4970 high-saturated-fat diet NOT increases_expression of PPARGC1A
5035 PPARGC1A affects_expression of UCP1
5041 Thiazolidinedione increases_expression of PPARGC1A
5092 PPARGC1A affects_activity of Diabetes mellitus, type II
5104 PPARGC1A affects_activity of Insulin resistance
5105 PPARGC1A increases_expression of TRIB3 in skeletal muscle
5125 Diabetes mellitus, type II decreases_expression of PPARGC1A via hypermethylation of the PPARGC1A promoter
5132 Resveratrol decreases_acetylation of PPARGC1A in high-fat fed mice
5133 Resveratrol increases_activity of PPARGC1A in high-fat fed mice
13113 PPARGC1A affects_activity of increased insulin sensitivity in liver
13117 Thiazolidinedione affects_activity of PPARGC1A
13128 PPARGC1A affects_expression of MT-CO2
13129 PPARGC1A affects_expression of COX4
13130 PPARGC1A increases_activity of Mitochondrial respiratory chain
13131 PPARGC1A affects_activity of fatty acid beta-oxidation
19770177 Diabetes mellitus, type II
Obesity
Insulin resistance
868
5208 SIRT1 decreases_acetylation of PPARGC1A in skeletal muscle; if SIRT1 is overexpressed
18840364 Diabetes mellitus, type II
Insulin resistance
886
5234 PPARGC1A affects_activity of Diabetes mellitus, type II
12107756 Diabetes mellitus, type II
Insulin resistance
904
13192 SIRT1 increases_activity of PPARGC1A on standard diet, on high-fat diet, if SIRT1 is overexpressed
18599449 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
906
5480 SIRT1 affects_acetylation of PPARGC1A if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
19549853 Diabetes mellitus, type II
Insulin resistance
947
5768 SIRT1 affects_expression of PPARGC1A in liver; after overnight fasting, if SIRT1 is knocked out in liver
5788 SIRT1 increases_activity of PPARGC1A
5850 SIRT1 affects_expression of PPARGC1A in liver; on high-fat diet, if SIRT1 is knocked out in liver
19356714 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
1,016
6332 PPARGC1A increases_expression of SOD2
6335 PARK7 increases_activity of PPARGC1A
6337 PPARGC1A interacts (colocalizes) with SFPQ
6343 SFPQ decreases_activity of PPARGC1A
6346 PARK7 NOT interacts (colocalizes) with PPARGC1A
18689799 Parkinson disease
1,179
7814 NOS2 affects_expression of PPARGC1A
20532036 Diabetes mellitus, type II
Obesity
Insulin resistance
1,232
8404 C3AR1 NOT affects_expression of PPARGC1A in brown adipose tissue
19581423 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
1,409
10033 Anakinra NOT affects_expression of PPARGC1A in muscle
17429083 Diabetes mellitus, type II
Insulin resistance
1,439
10132 IL18 NOT affects_expression of PPARGC1A in liver
16732281 Diabetes mellitus, type II
Obesity
Insulin resistance
1,450
10229 IL6 decreases_expression of PPARGC1A in skeletal muscle; if IL6 is overexpressed in skeletal muscle
10237 IL6 decreases_expression of PPARGC1A in liver; if IL6 is overexpressed in skeletal muscle
18437347 Diabetes mellitus, type II
Insulin resistance
1,513
10714 Resveratrol increases_activity of PPARGC1A in mice on high-calorie diet
17086191 Diabetes mellitus, type II
Insulin resistance
1,547
11054 PPARGC1A affects_activity of mitochondrion organization
11055 PPARGC1A decreases_activity of neuron death if neuron death has been induced by SNCA overexpression or rotenone
11056 PPARGC1A decreases_activity of SNCA-p.A53T if neuron death has been induced by SNCA-A53T
11058 PPARGC1A increases_activity of Mitochondrial respiratory chain
11060 Parkinson disease decreases_activity of PPARGC1A
20926834 Parkinson disease
1,559
11196 ADIPOQ affects_expression of PPARGC1A in adipose tissue
17717599 Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
2,039
16285 Angiotensin II decreases_expression of PPARGC1A via AGTR2
16287 AGTR2 affects_expression of PPARGC1A
16288 AGTR1 NOT affects_expression of PPARGC1A
16292 PPARGC1A affects_activity of mitochondrion organization
19074984 Diabetes mellitus, type II
Insulin resistance
2,266
19350 SPP1 affects_expression of PPARGC1A in liver
21562757 Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
2,539
23640 Diabetes mellitus, type II decreases_expression of PPARGC1A
23641 PPARGC1A affects_activity of insulin secretion
23642 PPARGC1A rs8192678 decreases_expression of PPARGC1A
23644 Diabetes mellitus, type II decreases_expression of PPARGC1A in pancreas, in pancreatic islets; via increased promoter DNA methylation
18270681 Diabetes mellitus, type II
Insulin resistance
2,689
25170 PPARGC1A interacts (colocalizes) with ESRRA
25171 PPARGC1A increases_activity of ESRRA
12522104 Endocrine
Postpartum depression
3,181
29160 PPARGC1A affects_activity of mitochondrion organization
29169 Alzheimer disease decreases_expression of PPARGC1A in both AD hippocampal tissues and APPswe M17 cells
29198 cAMP increases_expression of PPARGC1A in APPswe M17 cells
29205 APPswe M17 cell decreases_expression of PPARGC1A
29212 PKA inhibitor H89 decreases_expression of PPARGC1A in APPswe M17 cells
29239 PKA/CREB pathway affects_expression of PPARGC1A in APPswe M17 cells
22077634 Alzheimer disease
3,185
29250 Alzheimer disease decreases_expression of PPARGC1A in AD brain
29255 PPARGC1A affects_activity of amyloidosis PGC-1alpha content is inversely correlated with total Abetax-42 content
62466 PPARGC1A affects_quantity of Amyloid beta peptide PGC-1alpha content is inversely correlated with total Abetax-42 content
19273754 Alzheimer disease
3,615
34135 Cholic acid increases_expression of PPARGC1A in brown adipose tissue
16400329 Diabetes mellitus, type II
Obesity
Insulin resistance
3,617
34203 Colestimide increases_expression of PPARGC1A in liver
34212 Colestimide increases_expression of PPARGC1A in brown adipose tissue
34213 Cholic acid increases_expression of PPARGC1A in brown adipose tissue
34216 Colestimide NOT affects_expression of PPARGC1A in muscle
34217 Cholic acid NOT affects_expression of PPARGC1A in muscle
22952571 Diabetes mellitus, type II
Insulin resistance
3,619
34234 high-fat diet, salmon protein hydrolysate-based NOT increases_expression of PPARGC1A in interscapular brown adipose tissue
34235 high-fat diet, salmon protein hydrolysate-based increases_expression of PPARGC1A in white adipose tissue
21680746 Diabetes mellitus, type II
Insulin resistance
Metabolic syndrome
3,622
34328 Triiodothyronine increases_expression of PPARGC1A
21941681 Diabetes mellitus, type II
Insulin resistance
Hypothyroidism
Hyperthyroidism
3,778
36977 high-fat diet decreases_expression of PPARGC1A in skeletal muscle
15983191 Diabetes mellitus, type II
Insulin resistance
3,779
36992 high-fat diet decreases_expression of PPARGC1A in skeletal muscle
15983191 Diabetes mellitus, type II
Insulin resistance
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