Search Results for "PARK2" - 161 interactions found in 35 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
517
9824 PRKN decreases_activity of abnormal mitochondrial physiology
45616 PRKN increases_activity of autophagy of mitochondrion together with Pink1
19966284 Parkinson disease
823
4759 PRKN NOT interacts (colocalizes) with UBE2B
4760 PRKN NOT interacts (colocalizes) with CDC34
4761 PRKN NOT interacts (colocalizes) with UBE2D2
4762 PRKN NOT interacts (colocalizes) with UBE2D1
4763 PRKN NOT interacts (colocalizes) with UBE2D3
4764 PRKN NOT interacts (colocalizes) with UBE2E1
4765 PRKN increases_activity of protein ubiquitination
10888878 Parkinson disease 2, autosomal recessive juvenile
Parkinson disease
825
4774 PRKN is localized in alpha-synuclein inclusion body in brainstem
4776 PRKN interacts (colocalizes) with UBE2L3 in brainstem
4779 PRKN increases_ubiquitination/sumoylation of SNCA
11431533 Parkinson disease
878
5169 PRKN interacts (colocalizes) with EPS15
5172 PRKN affects_activity of epidermal growth factor receptor signaling pathway
16862145 Parkinson disease
879
5174 PRKN increases_ubiquitination/sumoylation of EPS15
5176 PRKN decreases_activity of receptor-mediated endocytosis
5206 PRKN affects_quantity of EGFR after EGF stimulation
5212 PRKN increases_activity of protein kinase B signaling after EGF stimulation
16862145 Parkinson disease
885
5221 PRKN NOT increases_phosphorylation of MAPK1 in synaptosomes
5223 PRKN increases_activity of protein kinase B signaling in synaptosomes
5224 PRKN NOT increases_phosphorylation of AKT1 in synaptosomes
16862145 Parkinson disease
888
5248 PRKN decreases_activity of Staurosporine
5249 PRKN decreases_activity of 6-OHDA
5251 PRKN decreases_expression of TP53
5255 PRKN decreases_activity of TP53
5262 PRKN decreases_activity of CASP3
19801972 Parkinson disease
890
5256 PRKN decreases_activity of CASP3 induced by 6-OHDA
5257 PRKN decreases_activity of TP53
5258 PRKN decreases_expression of TP53
19801972 Parkinson disease
891
5259 PRKN decreases_expression of TP53
19801972 Parkinson disease
893
5264 PRKN increases_activity of CASP3 induced by 6-OHDA
5265 PRKN decreases_expression of TP53
5266 PRKN decreases_activity of TP53
5284 PRKN interacts (colocalizes) with TP53 at the p53 promoter region
19801972 Parkinson disease
900
16457 PRKN decreases_activity of cell cycle by increasing ubiquitination of cyclin E resulting in increased degradation of cyclin E
16461 PRKN affects_activity of Glioblastoma
19946270 Glioblastoma
Parkinson disease
962
5909 PRKN is localized in mitochondrion after CCCP treatment
5910 PRKN increases_ubiquitination/sumoylation of mitochondrion after CCCP treatment
20404107 Parkinson disease
963
5918 PRKN is localized in mitochondrion after CCCP treatment
5919 PRKN increases_activity of autophagy of mitochondrion after CCCP treatment
5920 PINK1 increases_transport of PRKN into mitochondria; after CCCP treatment
5937 PINK1-p.E240K increases_transport of PRKN into mitochondria; after CCCP treatment
5938 PINK1-p.G309D increases_transport of PRKN into mitochondria; after CCCP treatment
5939 PINK1-n.[1602-1603insCAA] NOT increases_transport of PRKN into mitochondria; after CCCP treatment
20404107 Parkinson disease
1,389
9560 PRKN interacts (colocalizes) with YWHAH
9562 PRKN NOT interacts (colocalizes) with YWHAB
9563 PRKN NOT interacts (colocalizes) with YWHAG
9564 PRKN NOT interacts (colocalizes) with YWHAE
9565 PRKN NOT interacts (colocalizes) with YWHAQ
9569 PRKN increases_activity of protein ubiquitination
9573 PRKN increases_ubiquitination/sumoylation of SNCAIP
9574 PRKN interacts (colocalizes) with SNCAIP
9576 YWHAH decreases_ubiquitination/sumoylation of PRKN via suppression of PARK2 ubiquitin-ligase activity
9577 YWHAH decreases_activity of PRKN via suppression of PARK2 ubiquitin-ligase activity
9584 PRKN interacts (colocalizes) with UBE2L3 irrespective of 14-3-3 eta
9585 PRKN interacts (colocalizes) with UBE2G2 irrespective of 14-3-3 eta
16096643 Parkinson disease 2, autosomal recessive juvenile
Parkinson disease
1,412
9765 PINK1 decreases_quantity of PRKN in mitochondria; under stress conditions
9767 response to stress decreases_quantity of PRKN in mitochondria; only in the presence of WT PINK1
9769 PINK1-p.Q456X NOT decreases_quantity of PRKN in mitochondria; under stress conditions
9770 PINK1-p.V170G NOT decreases_quantity of PRKN in mitochondria; under stress conditions
9771 PINK1 NOT decreases_expression of PRKN in mitochondria; under stress conditions
9779 PRKN is localized in cytoplasm under basal conditions
9780 H2O2 increases_transport of PRKN into mitochondria
9781 PRKN is localized in mitochondrion under stress conditions
9782 PINK1 increases_transport of PRKN into mitochondria; under stress conditions
9783 PINK1-p.Q456X NOT increases_transport of PRKN into mitochondria; under stress conditions
9785 PINK1-p.V170G NOT increases_transport of PRKN into mitochondria; under stress conditions
20508036 Parkinson disease
1,419
9848 mitochondrial depolarization increases_transport of PRKN into depolarized mitochondria; in the presence of accumulated PINK1 in depolarized mitochondria
9852 PINK1 increases_transport of PRKN into depolarized mitochondria
9856 PRKN increases_activity of autophagy of mitochondrion of depolarized mitochondria in the presence of accumulated PINK1
9857 PINK1-p.L347P NOT increases_transport of PRKN into depolarized mitochondria
9858 PINK1-p.A168P NOT increases_transport of PRKN into depolarized mitochondria
9859 PINK1-p.H271Q NOT increases_transport of PRKN into depolarized mitochondria
20126261 Parkinson disease
1,424
9922 PINK1 increases_expression of PRKN
9924 PINK1 increases_quantity of PRKN
9925 PINK1-p.G309D decreases_expression of PRKN
9926 PINK1-p.G309D decreases_quantity of PRKN
20045449 Parkinson disease
1,438
10077 PRKN is localized in cytoplasm
10078 PRKN is localized in mitochondrion
10079 PRKN interacts (colocalizes) with mitochondrial chromosome also in vivo in mouse brain
10080 PRKN increases_activity of mitochondrial DNA replication
10081 PRKN increases_activity of mitochondrial transcription
10084 PRKN NOT affects_quantity of Reactive oxygen species in mitochondria
10085 PRKN decreases_activity of response to oxidative stress in mitochondria
10087 PRKN increases_activity of mitochondrial DNA repair
19617636 Parkinson disease
1,447
10153 PRKN increases_activity of autophagy of mitochondrion after CCCP treatment
10284 PRKN affects_activity of dynein complex
10285 PRKN increases_ubiquitination/sumoylation of mitochondrion after CCCP treatment
10290 PRKN affects_activity of HDAC6 by increasing ubiqitination signals in mitochondria
20457763 Parkinson disease
1,458
10304 mitochondrial depolarization increases_transport of PRKN into mitochondria; after CCCP treatment
10306 PINK1 increases_transport of PRKN into mitochondria; after CCCP treatment
10307 mitochondrial depolarization increases_activity of PRKN after CCCP treatment
20724841 Parkinson disease
1,461
10313 PRKN affects_activity of PINK1
10324 PRKN affects_ubiquitination/sumoylation of MFN1 after CCCP treatment and in the presence of PINK1
10325 PRKN affects_ubiquitination/sumoylation of MFN2 after CCCP treatment and in the presence of PINK1
11680 PRKN affects_activity of Parkinson disease
20871098 Parkinson disease
1,470
10382 mouse-qk(v) decreases_quantity of PRKN
15014970 Neurological
Parkinson disease
1,477
10409 PRKN increases_activity of protein K63-linked ubiquitination in mitochondria; if PARK2 is localized in mitochondria
10412 PRKN increases_quantity of SQSTM1 in mitochondria; if PARK2 is localized in mitochondria
10414 PRKN increases_transport of SQSTM1 into mitochondria; if PARK2 is localized in mitochondria
20890124 Parkinson disease
1,479
10419 mitochondrial depolarization increases_quantity of PRKN in mitochondria; if mitochondrial depolarisation has been induced by CCCP treatment
10423 CCCP increases_quantity of PRKN in mitochondria
10427 PRKN increases_activity of autophagy of mitochondrion if mitochondria are damaged
10431 DNAJB2 affects_folding of PRKN thus enabling mitophagy of damaged mitochondria
10452 DNAJB2 interacts (colocalizes) with PRKN
20889486 Parkinson disease
1,482
10464 PRKN interacts (colocalizes) with BCL2
10466 PRKN interacts (colocalizes) with BAX
10467 PRKN increases_ubiquitination/sumoylation of BCL2
10468 PRKN increases_quantity of BCL2
10476 PRKN affects_activity of autophagy via regulating Bcl-2 stability
20889974 Parkinson disease
1,483
10477 PRKN interacts (colocalizes) with GPR37
10478 PRKN interacts (colocalizes) with UBE2J1
10479 PRKN interacts (colocalizes) with UBC7
10480 PRKN increases_ubiquitination/sumoylation of GPR37
10481 PRKN decreases_quantity of GPR37 via ubiquitin-mediated proteasomal degradation
10482 endoplasmic reticulum unfolded protein response increases_quantity of PRKN
11439185 Parkinson disease 2, autosomal recessive juvenile
Parkinson disease
1,485
10488 PRKN interacts (colocalizes) with SYT11
10489 PRKN increases_ubiquitination/sumoylation of SYT11
10490 PRKN decreases_quantity of SYT11 via ubiquitin-mediated proteasomal degradation
12925569 Parkinson disease 2, autosomal recessive juvenile
Parkinson disease
1,487
10501 PRKN interacts (colocalizes) with RANBP2
10505 PRKN increases_ubiquitination/sumoylation of RANBP2
10506 PRKN decreases_quantity of RANBP2 via ubiquitin-mediated proteasomal degradation
10509 PRKN affects_quantity of HDAC4
10511 PRKN decreases_quantity of RANBP2 via the ubiquitin proteasomal pathway
16332688 Parkinson disease 2, autosomal recessive juvenile
Parkinson disease
1,488
10514 PRKN interacts (colocalizes) with AIMP2
10515 PRKN increases_ubiquitination/sumoylation of AIMP2
10517 PRKN decreases_quantity of AIMP2 via ubiquitin-mediated proteasomal degradation
12783850 Parkinson disease
1,491
10528 PRKN interacts (colocalizes) with FUBP1
10529 PRKN increases_ubiquitination/sumoylation of FUBP1
10530 PRKN decreases_quantity of FUBP1 via the ubiquitin proteasomal pathway
16672220 Dementia, Lewy body
Parkinson disease 2, autosomal recessive juvenile
Parkinson disease
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