General Information:

Id: 947 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background
Reference: Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 9: 327-338 [PMID: 19356714]

Interaction Information:

Comment Several proinflammatory molecules that are dramatically induced in PPAR-alpha deficient livers, such as vascular cell adhesion molecule (VCAM-1), serum amyloid A-1 (SAA-1), and interferon (IFN)-gamma inducible protein (CXCL10), were significantly higher in livers of SIRT1 LKO mice compared to Lox controls.
Formal Description
Interaction-ID: 5888



affects_quantity of



in liver; if SIRT1 is knocked out in liver
Drugbank entries Show/Hide entries for CXCL10