General Information:

Id: 947 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background
Reference: Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 9: 327-338 [PMID: 19356714]

Interaction Information:

Comment ER stress provokes an ER transmembrane protein kinase, pancreatic ER kinase (PERK), to phosphorylate the alpha subunit of the translation initiation factor (eIF2-alpha) thus blocking cellular protein translation. Comparison of levels of phosphorylated eIF2-alpha in liver extracts of control and SIRT1 LKO mice revealed that SIRT1 LKO mice had a 2.2-fold increase in p-eIF2-alpha protein compared to Lox controls.
Formal Description
Interaction-ID: 5862



affects_quantity of

protein modification


in liver; if SIRT1 is knocked out in liver