General Information:

Id: 947 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background
Reference: Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 9: 327-338 [PMID: 19356714]

Interaction Information:

Comment To elucidate the regulatory role of SIRT1 in PPAR-alpha signaling in liver, primary hepatocytes from Lox control or SIRT1 LKO mice were treated with a PPAR-alpha agonist WY14643. WY treatment induced the expression of several genes involved in fatty acid oxidation in control hepatocytes. However, the induction of these genes was significantly lower in the SIRT1 deficient (LKO) hepatocytes.
Formal Description
Interaction-ID: 5777



affects_activity of

in liver