General Information:

Id: 906 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
SirT1 ASO: knockdown of SirT1 expression in liver and adipose tissue, diabetic via initial streptozotocin injection and 4 weeks of fructose- and high-fat-feeding
Reference: Erion DM et al.(2009) SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc. Natl. Acad. Sci. U.S.A. 106 [PMID: 19549853]

Interaction Information:

Comment SirT1 ASO decreased SirT1 mRNA expression by 77% in liver, and the drop in mRNA corresponded with a 68% decrease in SirT1 protein. Additionally, SirT1 ASO decreased SirT1 mRNA 91% in the adipocyte. In addition, no difference was found in SirT1 mRNA in muscle and a tendency of decreased SirT1 mRNA in brown adipose tissue (BAT).
Formal Description
Interaction-ID: 5402

organism model

SirT1 ASO rat

decreases_expression of



in liver, in white adipose tissue, in brown adipose tissue